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Analysis of temperature dependence of fat proton magnetic resonance signal for quantitative temperature imaging

Research Project

Project/Area Number 24500516
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokai University

Principal Investigator

KURODA Kagayaki  東海大学, 情報理工学部, 教授 (70205243)

Co-Investigator(Kenkyū-buntansha) IMAI Yutaka  東海大学, 医学部, 教授 (70138113)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMRI / 温度 / 非侵襲 / 画像 / 脂肪 / T1 / メチレン / 信号 / 磁気共鳴 / 画像化 / 依存性 / プロトン / 集束超音波 / 緩和時間
Outline of Final Research Achievements

In order to execute high intensity focused ultrasound (HIFU) therapy for breast and bone marrow safely and effectively, we planned to establish a noninvasive and quantitative temperature imaging technique using spin-lattice relaxation time (T1) of proton of methylene chain observed by magnetic resonance imaging (MRI). Based on a new finding that the signal intensity ratio of the chemical shift components of fatty acid in bovine and porcine tissues is insensitive to temperature, we have proposed a novel T1 estimation technique using the ratio among the nine fat signal components as a prior knowledge in the image processing following multiple-point Dixon and multiple flip angle imaging. The usefulness and robustness of the technique was demonstrated with numerical simulation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Quality assurance: Recommended guidelines for safe heating by capacitive-type heating technique to treat patients with metallic implants2013

    • Author(s)
      Kato H, Kondo M, Imada H, Kuroda M, Kamimura Y, Saito K, Kuroda K, Ito K, Takashi H, Matsuki H
    • Journal Title

      Int J Hyperthermia

      Volume: 29(3) Issue: 3 Pages: 194-205

    • DOI

      10.3109/02656736.2013.774059

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of noninvasive temperature imaging of fat based on magnetic resonance relaxation times of lipid proton components2012

    • Author(s)
      Kuroda K, Morita S, Lam MK, Obara M, Baron P, Bartels W, Honda M, Horie H, Imai Y.
    • Journal Title

      Thermal Medicine

      Volume: 28(4) Pages: 87-96

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Signal processing for noninvasive temperature imaging of fat and aqueous tissues using methylene T1 and water proton resonance frequency2014

    • Author(s)
      Morita S, Obara M, Honda M, Imai Y, Kuroda K
    • Organizer
      Proc 10th Interventional MRI Symposium 2014(P-37):p.126
    • Place of Presentation
      The Westin Leiptig, Leiptig, Germany
    • Year and Date
      2014-10-10 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Signal Processing for Noninvasive Temperature Imaging of Fat using Spin-Lattice relaxation time of Proton Magnetic Resonance2014

    • Author(s)
      Morita S, Lam MK, Bartels W, Imai Y, Kuroda K
    • Organizer
      Proc 6th Asian Congress of Hyperthermic Oncology & 31st Japanese Congress of Thermal Medicine, Thermal Medicne, Thermal Medicine 2014; 30(Supplement):p. 85
    • Place of Presentation
      AOSSA Fukui, Fukui, Japan
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪組織プロトン磁気共鳴のスピン格子緩和時間による非侵襲温度分布画像化における信号処理法の検討2013

    • Author(s)
      森田修平, Mie Kee Lam, Wilbert Bartels, 今井 裕, 黒田 輝
    • Organizer
      日本ハイパーサーミア学会第30回大会
    • Place of Presentation
      横浜シンポジア(横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪プロトン成分信号のT1による温度分布画像化における信号処理法の検討2013

    • Author(s)
      森田修平, Mie Kee Lam, Wilbert Bartels, 今井 裕, 黒田 輝
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      アスティ徳島(徳島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Noninvasive Magnetic Resonance Temperature Imaging2013

    • Author(s)
      Kagayaki Kuroda
    • Organizer
      Biomedical Engineering International Conference 2013 (BMEiCON2013)
    • Place of Presentation
      Krabi, Thailand
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Proton Density Ratio Consideration in Optimizing Image Processing in Fat-Water Thermometry using Methylene T1 and Water Resonance Frequency2012

    • Author(s)
      Kuroda K, Takano Y, Obara M, Baron P, Lam MK, Bartels WL, Masatoshi H, Imai Y
    • Organizer
      Proc 20 th Annual Meeting Intl Soc Mag Reson Med 2012;20:p. 1562
    • Place of Presentation
      Melbourne Convention & Exhibition Centre (Melbourne, Australia)
    • Related Report
      2012 Research-status Report
  • [Presentation] Temperature dependence of magnetic resonance signals of lipid proton components and its application to fat thermometry2012

    • Author(s)
      Kuroda K, Morita S, Albarodi K, Obara M, Baron P, Lam MK, Bartels W, Honda M, Horie T, Imai Y
    • Organizer
      Thermal Medicine , Proc The 11th International Congress of Hyperthermic Oncology (ICHO) and The 29th Japanese Congress of Themal Medicine (JCTM) 2012;28(Suppl):p. 137
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Progress in noninvasive MR thermometry2012

    • Author(s)
      Kuroda K
    • Organizer
      Proc The 11th International Congress of Hyperthermic Oncology (ICHO) and The 29th Japanese Congress of Themal Medicine (JCTM) 2012;28(Suppl):p. 71
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 磁気共鳴による非侵襲温度分布画像化:メチレン基スピン格子緩和時間による脂肪温度計測手法の最適化

    • Author(s)
      森田修平, 本田真俊, 小原 真, 堀江朋彦, 今井 裕, 黒田 輝
    • Organizer
      関東ハイパーサーミア研究会
    • Place of Presentation
      東京厚生年金病院(東京都)
    • Related Report
      2012 Research-status Report
  • [Book] Temperature Monitoring by Chemical Shift-Based Method, in Handbook of in vivo Magnetic Resonance Spectroscopy2015

    • Author(s)
      Kuroda K
    • Total Pages
      12
    • Publisher
      John Wiley & Sons, Ltd
    • Related Report
      2014 Annual Research Report
  • [Remarks] BMEiCON2013 Keynote Speakers

    • URL

      http://www.bmeicon.org/download/CV_kuroda.pdf

    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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