| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Calcium phosphates, such as hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Immunotherapy without side effects has been expected as a novel medical treatment for a cancer. Among some immunotherapies, we have focused on the lymphokine activated killer cell (LAK) therapy. In order to develop the novel cell-culture substrates for enhancing the activity of immune cells, we have created the two kinds of “immunoceramics”: i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on the above immnoceramics to assay the activation ability by a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The two immunoceramics may be expected as key materials for next-generation immunotherapy.
|
