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Development of immunoceramics acting on immune system and their functions

Research Project

Project/Area Number 24500531
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionMeiji University

Principal Investigator

AIZAWA Mamoru  明治大学, 理工学部, 教授 (10255713)

Co-Investigator(Renkei-kenkyūsha) NAGAI Shigenori  東京医科歯科大学大学院, 医歯学総合研究科, 准教授 (50348801)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsイムノセラミックス / 水酸アパタイト / イノシトールリン酸 / ホウ素含有アパタイト / 免疫細胞 / T細胞 / フローサイトメーター / 養子免疫療法 / バイオマテリアル / バイオセラミックス / アパタイト / NK細胞 / フローサイトメトリー
Outline of Final Research Achievements

Calcium phosphates, such as hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Immunotherapy without side effects has been expected as a novel medical treatment for a cancer. Among some immunotherapies, we have focused on the lymphokine activated killer cell (LAK) therapy. In order to develop the novel cell-culture substrates for enhancing the activity of immune cells, we have created the two kinds of “immunoceramics”: i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on the above immnoceramics to assay the activation ability by a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The two immunoceramics may be expected as key materials for next-generation immunotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (34 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Azaspirene analogs inhibit the growth of human uterine carcinosarcoma in vitro2015

    • Author(s)
      M. Emoto, K. Yano, B. Choijamts, S. Sakai, S. Hirasawa, S. Wakamori, M. Aizawa, K. Nabeshima, K. Tachibana, and N. Kanomata
    • Journal Title

      Anticancer Research

      Volume: 35 Pages: 2739-2746

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatibility of silver-containing calcium-phosphate cements with anti-bacterial properties2015

    • Author(s)
      Y. Shimizu, Y. Kawanobe, T. Konishi, N. Kanzawa, M. Honda, M. Aizawa
    • Journal Title

      Key Eng. Mater.

      Volume: 631 Pages: 107-112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity, and antibacterial properties2014

    • Author(s)
      H. Kakinuma, K. Ishii, H. Ishihama, M. Honda, Y. Toyama, M. Matsumoto, M. Aizawa
    • Journal Title

      J. Biomed. Mater. Res. A

      Volume: 103A Issue: 1 Pages: 57-64

    • DOI

      10.1002/jbm.a.35157

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo antimicrobial properties of silver-containing hydroxyapatite prepared via ultrasonic spray pyrolysis route2013

    • Author(s)
      M. Honda, N. Kanzawa and M. Aizawa
    • Journal Title

      Mater Sci Eng C

      Volume: 35 Issue: 8 Pages: 5008-5018

    • DOI

      10.1016/j.msec.2013.08.026

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrications of Boron-Containing Apatite Ceramics via Ultrasonic Spray-Pyrolysis Route and Their Surface Properties2013

    • Author(s)
      M. Nakamura, Z. Zhuang and M. Aizawa
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 109-113

    • DOI

      10.4028/www.scientific.net/kem.529-530.109

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In Vitro Biological Evaluation of Anti-Tumor Effect of the Chelate-Setting Hydroxyapatite Cement2013

    • Author(s)
      M. Honda, T. Konishi, M. Mizumoto, and M. Aizawa
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 173-177

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Studies on the Anti-Tumor Action of Chelate-Setting Apatite Cements2013

    • Author(s)
      T. Inayama, H. Konishi, M. Aizawa, and N. Kanzawa
    • Journal Title

      Key Engineering Materials

      Volume: 529-530 Pages: 178-182

    • DOI

      10.4028/www.scientific.net/kem.529-530.178

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biochemical Studies of the Potential anti-tumor Activity of Novel Chelate-Setting Apatite Cements2012

    • Author(s)
      H. Konishi, M. Honda, M. Aizawa and N. Kanzawa
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 315-319

    • DOI

      10.4028/www.scientific.net/kem.493-494.315

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The effects of carbonated hydroxyapatite on macrophage behaviors2014

    • Author(s)
      K. Igeta, A. Nagai, M. Aizawa, K. Yamashita
    • Organizer
      26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (26 Bioceramics)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cellular responses of immune cells derived from mouse spleen to hydroxyapatite ceramics surface-modified with inositol phosphate2014

    • Author(s)
      K. Yamada, M. Nakamura, S. Nagai, M. Honda, M. Aizawa
    • Organizer
      26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (26 Bioceramics)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of anti-bacterial calcium-phosphate cements consisting of -tricalcium phosphate and silver-containing hydroxyapatite and their cytotoxicity2014

    • Author(s)
      Y. Shimizu, Y. Kawanobe, T. Konishi, N. Kanzawa, M. Honda, M. Aizawa
    • Organizer
      26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (26 Bioceramics)
    • Place of Presentation
      スペイン、バルセロナ
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炭酸含有アパタイトの合成とマクロファージ接着に与える影響2014

    • Author(s)
      井ヶ田一貴・永井亜希子・相澤 守・山下仁大
    • Organizer
      第24回 無機リン化学討論会
    • Place of Presentation
      高知
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] イノシトールリン酸を表面修飾した水酸アパタイトセラミックスに対するマウス脾臓由来免疫細胞の応答性2014

    • Author(s)
      山田清貴・中村まり子・永井重徳・本田みちよ・相澤 守
    • Organizer
      第24回 無機リン化学討論会
    • Place of Presentation
      高知
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of particles sizes on anti-tumorigenesis of biodegradable calcium-phosphate hollow microsphere loaded with anti-angiogenic agent2014

    • Author(s)
      M. Aizawa, H. Yoshihisa, Y. Naganuma, B. Choijiamts, K. Yano and M. Emoto
    • Organizer
      International Union of Materials Research – The 15th IUMRS International Conference in Asia (IUMRS-ICA 2014)
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-24 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] イノシトールリン酸のキレート能を利用した銀担持アパタイトによる抗菌性PEEKインプラントの創製とその生体適合性2014

    • Author(s)
      柿沼祐亮・石井 賢・石濱寛子・本田 みちよ・戸山芳昭・松本守雄・相澤 守
    • Organizer
      無機マテリアル学会 第128回 学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] イノシトールリン酸のキレート能を利用した銀担持アパタイトによる抗菌性インプラントの創製とその生体適合性2014

    • Author(s)
      柿沼祐亮・石井賢・石濱寛子・本田みちよ・戸山芳昭・松本守雄・相澤守
    • Organizer
      日本セラミックス協会 2014年年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス、横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 銀含有リン酸カルシウムセメントの創製とその生物学的評価2013

    • Author(s)
      本田みちよ・水本みのり・川延勇介・清水友亮・持田直樹・小西敏功・石井賢・松本守雄・相澤守
    • Organizer
      無機マテリアル学会 第126回 学術講演会
    • Place of Presentation
      千葉県船橋市
    • Related Report
      2013 Research-status Report
  • [Presentation] Surface Property of Nitrogen-Doped Hydroxyapatite Ceramics and their Biocompatibility Evaluations Using Osteoblastic Cells2013

    • Author(s)
      Ryo Umeda, Satoshi Okuyama, Tomoaki Watanabe and Mamoru Aizawa
    • Organizer
      The 7th International Conference on the Science and Technology for Advance Ceramics (STAC-7)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Anti-Bacterial Property of Polyetheretherketone Implants Immobilized with Ag+ Ion on the Basis of Chelate-BondingAbility of Inositol Phosphate2013

    • Author(s)
      Hiroaki Kakinuma, Ken Ishii, Hiroko Ishihama, Yoshiaki Toyama, Morio Matsumoto and Mamoru Aizawa
    • Organizer
      The 7th International Conference on the Science and Technology for Advance Ceramics (STAC-7)
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] ホウ素含有アパタイトセラミックスと共存培養したマウス脾臓由来T, B, NK 細胞の細胞比率とその免疫評価2013

    • Author(s)
      中村まり子・永井重徳・相澤守
    • Organizer
      日本セラミックス協会 第26回秋季シンポジウム
    • Place of Presentation
      信州大学(長野キャンパス)
    • Related Report
      2013 Research-status Report
  • [Presentation] 銀担持アパタイトを被覆したポリエーテルエーテルケトンインプラントの創製とその抗菌特性2013

    • Author(s)
      柿沼祐亮・石井賢・石濱寛子・戸山芳昭・松本守雄・相澤守
    • Organizer
      日本セラミックス協会 第26回秋季シンポジウム
    • Place of Presentation
      信州大学(長野キャンパス)
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗菌性を備えた非崩壊型リン酸カルシウムセメントの作製とその細胞毒性2013

    • Author(s)
      清水友亮・川延勇介・小西敏功・本田みちよ・相澤守
    • Organizer
      第23回 無機リン化学討論会
    • Place of Presentation
      島根県松江市
    • Related Report
      2013 Research-status Report
  • [Presentation] Cellular response of immunocyte to boron-containing apatite ceramics (Best Poster Award受賞)2013

    • Author(s)
      Mariko Nakamura, Zhi Zhuang, Ryo Umeda, Shigenori Nagai, Mamoru Aizawa
    • Organizer
      International Symposium on Inorganic and Environmental Material 2013(ISIEM2013)
    • Place of Presentation
      Rennes, France
    • Related Report
      2013 Research-status Report
  • [Presentation] In vitro evaluation of nitrogen-doped hydroxyapatite ceramics using osteoblastic cells2013

    • Author(s)
      Ryo Umeda, Satoshi Okuyama, Mariko Nakamura, Tomoaki Watanabe, Mamoru Aizawa
    • Organizer
      International Symposium on Inorganic and Environmental Material 2013(ISIEM2013)
    • Place of Presentation
      Rennes, France
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗腫瘍効果を備えたキレート硬化型アパタイトセメントのin vitro評価2013

    • Author(s)
      目黒佑太・猪俣義彦・小西敏功・水本みのり・本田みちよ・相澤守
    • Organizer
      無機マテリアル学会 第127回 学術講演会
    • Place of Presentation
      山形県米沢市
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗菌薬を担持させた表面に細孔を備えたリン酸カルシウム微小球による抗菌性セメントの作製とその評価2013

    • Author(s)
      持田直輝・川延勇介・小西敏功・水本みのり・本田みちよ・羽田優理・神澤信行・相澤守
    • Organizer
      無機マテリアル学会 第127回 学術講演会
    • Place of Presentation
      山形県米沢市
    • Related Report
      2013 Research-status Report
  • [Presentation] 抗菌性を備えた非崩壊型リン酸カルシウムセメントの作製とその細胞毒性2013

    • Author(s)
      清水友亮・川延勇介・小西敏功・本田みちよ・水本みのり・相澤守
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      東京都江戸川区
    • Related Report
      2013 Research-status Report
  • [Presentation] イノシトールリン酸により銀イオンを固定化させたアパタイト被覆チタンインプラントの 抗菌特性2013

    • Author(s)
      呉哲宇・柿沼祐亮・本田みちよ・石井賢・戸山芳昭・松本守雄・相澤守
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      東京都江戸川区
    • Related Report
      2013 Research-status Report
  • [Presentation] In vitro evaluation of novel anti-bacterial Ti implant fabricated via fixation of silver ions on hydoxyapatite films surface-modified with inositol phosphate route2013

    • Author(s)
      Cheolwoo Oh, H. Kakinuma, M. Honda, T. Hoshikawa, K. Ishii, Y. Toyama, M. Matsumoto and M. Aizawa
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Fabrication of anti-bacterial polyetheretherketone implants immobilized with Ag+ ion on the basis of chelate-bonding ability of inositol phosphate and their material properties2013

    • Author(s)
      H. Kakinuma, K. Ishii, H. Ishihama, Y. Toyama, M. Matsumoto, and M. Aizawa
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Fabrication of anti-bacterial cement using calcium-phosphate microspheres loaded with vancomycin and its drug release2013

    • Author(s)
      N. Mochida, Y. Kawanobe, M. Honda, T. Konishi, M. Mizumoto, Y. Habuto, N. Kanzawa and M. Aizawa
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Surface property of nitrogen-doped hydroxyapatite ceramics and in vitro evaluation using osteoblasts2013

    • Author(s)
      R. Umeda, C. Izawa, M. Nakamura, T. Watanabe and M. Aizawa
    • Organizer
      13th Asian BioCeramics Symposium (ABC2013)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] ホウ素含有アパタイトセラミックスの作製とその免疫細胞応答性2013

    • Author(s)
      中村まり子・庄 志・永井重徳・相澤 守
    • Organizer
      第51回セラミックス基礎科学討論会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report
  • [Presentation] 窒素ドープ法により改質した水酸アパタイトセラミックスの表面特性およびその細胞応答性2013

    • Author(s)
      梅田 遼・奥山 慧・渡邉友亮・相澤 守
    • Organizer
      第51回セラミックス基礎科学討論会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report
  • [Presentation] 種々のイノシトールリン酸濃度で作製したキレート硬化型アパタイトセメントに対する腫瘍モデル細胞の細胞応答性2013

    • Author(s)
      目黒佑太・猪股義彦・小西敏功・水本みのり・本田みちよ・相澤 守
    • Organizer
      第51回セラミックス基礎科学討論会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Research-status Report
  • [Presentation] Fabrication of boron-containing apatite ceramics via ultrasonic spray-pyrolysis technique and its response to natural killer cell2012

    • Author(s)
      M. Nakamura, W. Hiraoka and M. Aizawa
    • Organizer
      9th World Biomaterials Congress
    • Place of Presentation
      Chengdu, China
    • Related Report
      2012 Research-status Report
  • [Presentation] 抗腫瘍効果を備えたキレート硬化型アパタイトセメントの作製とその評価2012

    • Author(s)
      目黒佑太・猪股義彦・小西敏功・水本みのり・本田みちよ・相澤 守
    • Organizer
      日本セラミックス協会 第25回秋季シンポジウム
    • Place of Presentation
      名古屋大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Studies on anti-tumor action of chelate-setting apatite cements2012

    • Author(s)
      T. Inayama, H. Konishi, M. Aizawa and N. Kanzawa
    • Organizer
      Bioceramics-24
    • Place of Presentation
      Kyushu University
    • Related Report
      2012 Research-status Report
  • [Presentation] Fabrications of boron-containing apatite ceramics via ultrasonic spray pyrolysis route and their surface properties2012

    • Author(s)
      M. Nakamura, Z. Zhuang and M. Aizawa
    • Organizer
      Bioceramics-24
    • Place of Presentation
      Kyushu University
    • Related Report
      2012 Research-status Report
  • [Presentation] In vitro evaluation of anti-tumor effect of the chelate-setting hydroxyapatite cement using inositol hexaphosphate2012

    • Author(s)
      M. Honda, T. Konishi, M. Mizumoto and M. Aizawa
    • Organizer
      Bioceramics-24
    • Place of Presentation
      Kyushu University
    • Related Report
      2012 Research-status Report
  • [Presentation] Studies on the anti-tumor action of a novel apatite cement2012

    • Author(s)
      T. Inayama, H. Konishi, M. Aizawa and N. Kanzawa
    • Organizer
      12th Asian BioCeramics (ABC2012) Symposium
    • Place of Presentation
      Tainan, Taiwan
    • Related Report
      2012 Research-status Report
  • [Presentation] Fabrication of nitrogen-doped hydroxyapatite ceramics and its surface characterization2012

    • Author(s)
      R. Umeda, S. Okuyama, T. Watanabe, and M. Aizawa
    • Organizer
      12th Asian BioCeramics (ABC2012) Symposium
    • Place of Presentation
      Tainan, Taiwan
    • Related Report
      2012 Research-status Report
  • [Remarks] 明治大学 理工学部 応用化学科 生体関連材料研究室

    • URL

      http://www.isc.meiji.ac.jp/~a_lab/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 明治大学 理工学部 応用化学科 生体関連材料研究室 (AIZAWA Lab.)

    • URL

      http://www.isc.meiji.ac.jp/~a_lab/

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞培養基材、細胞培養基材の製造方法、細胞培養方法、及び細胞培養装置2014

    • Inventor(s)
      相澤 守・中村まり子・山田清貴・永井重徳
    • Industrial Property Rights Holder
      相澤 守・中村まり子・山田清貴・永井重徳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-192763
    • Filing Date
      2014-09-22
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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