Development of immunoceramics acting on immune system and their functions
| Project/Area Number |
24500531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Shigenori 東京医科歯科大学大学院, 医歯学総合研究科, 准教授 (50348801)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | イムノセラミックス / 水酸アパタイト / イノシトールリン酸 / ホウ素含有アパタイト / 免疫細胞 / T細胞 / フローサイトメーター / 養子免疫療法 / バイオマテリアル / バイオセラミックス / アパタイト / NK細胞 / フローサイトメトリー |
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| Outline of Final Research Achievements |
Calcium phosphates, such as hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Immunotherapy without side effects has been expected as a novel medical treatment for a cancer. Among some immunotherapies, we have focused on the lymphokine activated killer cell (LAK) therapy. In order to develop the novel cell-culture substrates for enhancing the activity of immune cells, we have created the two kinds of “immunoceramics”: i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on the above immnoceramics to assay the activation ability by a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The two immunoceramics may be expected as key materials for next-generation immunotherapy.
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Report
(4 results)
Research Products
(45 results)
