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Development of targeted techniques of anticancer drug using magnetic fields

Research Project

Project/Area Number 24500541
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionKanazawa University

Principal Investigator

KAKIKAWA Makiko  金沢大学, 環日本海域環境研究センター, 助教 (10359713)

Co-Investigator(Kenkyū-buntansha) YAMADA Sotoshi  金沢大学, 環日本海域環境研究センター, 教授 (80019786)
KOBAYASHI Makoto  金沢医科大学, 医学部, 助教 (20460355)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsがん細胞 / 薬剤作用 / 交流磁場 / 抗がん剤
Outline of Final Research Achievements

Our results in previous study indicated that magnetic fields (60 Hz, 50 mT) enhance the potency of drugs in bacterial cells and suggested that magnetic fields change the permeability of cell membrane and increase drug uptake. If magnetic fields enable us to enhance the potency of anticancer drug on target region only, the dosage can be reduced and thus side effects can be suppressed in clinical cancer chemotherapy. In present study, we made a magnetic fields exposure system for cultured human cells and measured the effect of magnetic fields on a potency of anticancer drug, cisplatin to human lung cancer cell line. The viabilities of A549 cells treated with cisplatin only and cisplatin under magnetic fields exposure (60 Hz, 50 mT for 24 hours) were measured by colony assay. The result suggested that magnetic fields (60 Hz, 50 mT for 24 hours) enhance the potency of cisplatin on human cancer cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Increase in high-frequency magnetic fields due to parallel coils added to applicator for hyperthermia therapy2015

    • Author(s)
      Yamada S, Ikehata Y, Hayashi T, Ueno T, Kakikawa M,
    • Journal Title

      J.Magn. Soc. Jpn.

      Volume: 39 Pages: 80-84

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Extremely Low-Frequency (ELF) magnetic fields on the potency of drugs in bacterial cells2014

    • Author(s)
      4.Kakikawa M., Imai, S., Yamada S
    • Journal Title

      IEEE Transactions on Magnetics,

      Volume: 50 Issue: 4 Pages: 1-4

    • DOI

      10.1109/tmag.2013.2286781

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Control of exciting frequency of pancake applicator having wireless transmission for hyperthermia therapy2014

    • Author(s)
      Yamada S., Ikehata Y., Ueno T., Kakikawa M.,
    • Journal Title

      J. Magn. Soc. Jpn.,

      Volume: 38 Pages: 37-41

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High spatial resolution Non-contact measurement of low current signal by needle-type GMR probe2013

    • Author(s)
      Hoang H., Kakikawa M., Yamada S.
    • Journal Title

      日本AEM学会

      Volume: 21 Pages: 386-390

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 培養細胞における薬剤増強評価のための磁場曝露システム2013

    • Author(s)
      柿川真紀子, 山田外史, 池畑芳雄
    • Journal Title

      電気学会誌

      Volume: 133 Pages: 385-386

    • NAID

      10031175279

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 気を利用する体にやさしい治療-5, 磁界による抗がん剤作用の増強2013

    • Author(s)
      柿川真紀子,山田外史
    • Journal Title

      電気学会誌

      Volume: 133 Pages: 83-85

    • Related Report
      2013 Research-status Report
  • [Journal Article] Assessment of composition and origin of airborne bacteria in the free troposphere over Japan2013

    • Author(s)
      Teruya Maki
    • Journal Title

      Atmos. Environ.

      Volume: in press Pages: 1-1

    • DOI

      10.1016/j.atmosenv.2013.03.029

    • NAID

      120005254075

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Extremely Low-Frequency (ELF) magnetic fields on anticancer drugs potency2012

    • Author(s)
      Kakikawa M., et al.
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 48 Issue: 11 Pages: 2869-2872

    • DOI

      10.1109/tmag.2012.2200881

    • NAID

      120006323934

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Determination of calcium sensing receptor in the scales of goldfish and inductionof its mRNA expression by acceleration loading2012

    • Author(s)
      Kakikawa M., et al.
    • Journal Title

      Biological Sciences in Space

      Volume: 26 Pages: 26-31

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei Possible physiological roles of the calcitonin family in osmoregulation2012

    • Author(s)
      Suzuki N, Sekiguchi T, Satake H, Kato K, Nishiyama Y, Takahashi H, et al
    • Journal Title

      Gene

      Volume: 499 Issue: 2 Pages: 326-331

    • DOI

      10.1016/j.gene.2012.03.042

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト細胞に対する交流磁界曝露による抗がん剤シスプラチン作用への影響2015

    • Author(s)
      牛丸 透・柿川 真紀子・山田 外史
    • Organizer
      平成27年電気学会全国大会
    • Place of Presentation
      東京都市大学,東京
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト細胞への抗がん剤作用に対する交流磁界曝露影響2014

    • Author(s)
      牛丸透・柿川真紀子・山田外史
    • Organizer
      第38回日本磁気学会学術講演会
    • Place of Presentation
      慶応義塾大学,神奈川
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of magnetic fields on potency of anticancer drug cisplatin to human cancer cell line2014

    • Author(s)
      Kakikawa M, Ushimaru T, YamadaS.
    • Organizer
      Asia-pacific symposium on Applied Electromagnetics and mechanics
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2014-07-23 – 2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of ELF magnetic fields on anticancer drugs potency2012

    • Author(s)
      Kakikawa M. et al.
    • Organizer
      IEEE International Magnetics Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] The change of the membrane permeability of anticancer drugs by exposure to ELF magnetic fields2012

    • Author(s)
      Kakikawa M. et al.
    • Organizer
      Asia Pacific Symposium on Applied Electromagnetics and Mechanics
    • Place of Presentation
      Ho Chi Minh city, Vietnam
    • Related Report
      2012 Research-status Report
  • [Presentation] Sterilization Action on Cavitation Phenomenon Generated by Magnetostrictive2012

    • Author(s)
      Yamada S. et al.
    • Organizer
      Asia Pacific Symposium on Applied Electromagnetics and Mechanics
    • Place of Presentation
      Ho Chi Minh city, Vietnam
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト培養細胞における交流磁界曝露による抗がん剤薬効作用の増強2012

    • Author(s)
      森一也、柿川真紀子、山田外史
    • Organizer
      電気学会マグネティックス研究会
    • Place of Presentation
      九州大学、福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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