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Study of brain activity during dyspnea for the development of pulmonary rehabilitation to improve emotional distress

Research Project

Project/Area Number 24500611
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionShowa University

Principal Investigator

IZUMIZAKI Masahiko  昭和大学, 医学部, 教授 (20398697)

Co-Investigator(Renkei-kenkyūsha) HOMMA Ikuo  昭和大学, 医学部, 名誉教授 (20057079)
MASAOKA Yuri  昭和大学, 医学部, 講師 (70398692)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords呼吸困難 / 情動 / 脳内活動 / 脳波双極子追跡法 / 扁桃体 / 呼吸困難感 / 二酸化炭素 / 呼吸リハビリテーション
Outline of Final Research Achievements

We investigated brain areas associated with dyspnea using electroencephalogram dipole (EEG/DT) modeling. We measured EEG and respiration simultaneously during CO2 rebreathing, which induced dyspnea and allowed us to find inspiration-related potentials during dyspnea. Our EEG/DT modeling showed that the left superior frontal and left orbitofrontal cortex (OFC) were active during the 100 ms after inspiration onset. In the next 100 ms, the anterior cingulate cortex was activated, followed by the superior frontal and OFC. At 200 ms to 300 ms, dipoles finally converged in the left insula and amygdala. The first component of inspiration-related potentials involved frontal areas that play a role in the intention to inspire and emotional guidance, while the late component incorporated areas related to emotional reaction. Dyspnea with increasing ventilation could involve intentions to continue inspiration, and the perception of dyspnea could be associated with unpleasant emotions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Breathlessness-related brain activation: electroencephalogram dipole modeling analysis2015

    • Author(s)
      Taketoshi Seino, Yuri Masaoka, Katsunori Inagaki, Masahiko Izumizaki
    • Journal Title

      The Showa University Journal of Medical Sciences

      Volume: 印刷中

    • NAID

      130005096781

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breathing is affected by dopamine D2-like receptors in the basolateral amygdala2015

    • Author(s)
      Toshihisa Sugita, Mitsuko Kanamaru, Makito Iizuka, Kanako Sato, Setsuro Tsukada, Mitsuru Kawamura, Ikuo Homma, Masahiko Izumizaki
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 209 Pages: 23-27

    • DOI

      10.1016/j.resp.2014.09.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Where is the Rhythm Generator for Emotional Breathing?2014

    • Author(s)
      Yuri Masaoka, Masahiko Izumizaki, Ikuo Homma
    • Journal Title

      Progress in Brain Research

      Volume: 209 Pages: 367-377

    • DOI

      10.1016/b978-0-444-63274-6.00019-9

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Journal Article] Proprioceptive illusions created by vibration of one arm are altered by vibrating the other arm2014

    • Author(s)
      Naoyuki Hakuta, Masahiko Izumizaki, Kazuyoshi Kigawa, Norimitsu Murai, Takashi Atsumi, Ikuo Homma
    • Journal Title

      Experimental Brain Research

      Volume: 232 Issue: 7 Pages: 2197-2206

    • DOI

      10.1007/s00221-014-3911-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proprioceptive illusions created by vibration of one arm are altered by vibrating the other arm.2014

    • Author(s)
      Hakuta N, Izumizaki M, Kigawa K, Murai N, Atsumi T, Homma I.
    • Journal Title

      Exp Brain Res

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemosensory ventilatory responses in the mutant mice with Presbyterian hemoglobinopathy2013

    • Author(s)
      Pokorski M, Izumizaki M, Shirasawa T.
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 187 Issue: 1 Pages: 18-25

    • DOI

      10.1016/j.resp.2013.02.019

    • Related Report
      2013 Research-status Report
  • [Journal Article] Inhibitory Effect of Acupuncture on Vibration-Induced Finger Flexion Reflex in Humans: Comparisons Among Radial, Median, and Ulnar Nerve Stimulation.2013

    • Author(s)
      Yajima H, Takayama M, Kawase A, Takakura N, Izumizaki M, Homma I.
    • Journal Title

      Med Acupunct

      Volume: 25 Pages: 269-274

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of respiratory muscle stretch gymnastics on children's emotional response2013

    • Author(s)
      Toyodera T, Masaoka Y, Akai L, Hanaoka K, Ono S, Izumizaki M, Itahashi K, Homma I.
    • Journal Title

      Showa Univ J Med Sci

      Volume: 25 Pages: 171-179

    • NAID

      130004566596

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] CO2 homeostasis is maintained in conscious humans by regulation of tidal volume, but not of respiratory rhythm.2013

    • Author(s)
      Ohashi S, Izumizaki M, Atsumi T, Homma I.
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 186 Issue: 2 Pages: 155-163

    • DOI

      10.1016/j.resp.2013.01.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iwase M, Izumizaki M, Tsuchiya N, Homma I.2013

    • Author(s)
      Dopamine D1 receptors control exercise hyperpnoea in mice.
    • Journal Title

      Exp Physiol

      Volume: 98 Issue: 2 Pages: 491-500

    • DOI

      10.1113/expphysiol.2012.068312

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Izumizaki M, Iwase M, Tsuchiya N, Homma I.2013

    • Author(s)
      Hyperpnoeic response independent of limb movements at exercise onset in mice.
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 185 Issue: 2 Pages: 319-331

    • DOI

      10.1016/j.resp.2012.09.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction between vibration-evoked proprioceptive illusions and mirror-evoked visual illusions in an arm-matching task.2012

    • Author(s)
      Tsuge M, Izumizaki M, Kigawa K, Atsumi T, Homma I.
    • Journal Title

      Exp Brain Res

      Volume: 223 Issue: 4 Pages: 541-551

    • DOI

      10.1007/s00221-012-3281-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Synchronization between respiratory cycles and olfactory neural activations -EEG and fMRI study-2015

    • Author(s)
      Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Masahiro Ida, Ikuo Homma, Masahiko Izumizaki
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 息苦しさにおける脳内活動部位 Inspiration-related breathlessness in human brain2014

    • Author(s)
      清野毅俊、政岡ゆり、泉崎雅彦
    • Organizer
      第61回昭和大学学士会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸患者の無呼吸後の呼吸応答2014

    • Author(s)
      金丸 みつ子、横江 琢也、渡部 良雄、相良 博典、泉崎 雅彦
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Research-status Report
  • [Presentation] COPDの呼吸困難感のメカニズム2014

    • Author(s)
      泉崎雅彦
    • Organizer
      第21回板橋在宅呼吸ケア研究会開催
    • Place of Presentation
      ハイライフ板橋
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] COPDの息切れ機序2013

    • Author(s)
      泉崎雅彦
    • Organizer
      第23回神奈川在宅呼吸管理研究会
    • Place of Presentation
      横浜シンポジア
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] COPDの息切れの機序2013

    • Author(s)
      泉崎雅彦
    • Organizer
      第19回東京呼吸ケア研究会
    • Place of Presentation
      聖路加看護大学(東京)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] マウスにおける四肢運動非依存的運動時換気応答2013

    • Author(s)
      泉崎雅彦、岩瀬みち子、土屋尚人 、本間生夫
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] ドーパミンD1受容体はマウスの運動時換気亢進に代謝調節を介して寄与する2013

    • Author(s)
      岩瀬みち子、泉崎雅彦、土屋尚人 、本間生夫
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Research-status Report
  • [Book] 身体運動と呼吸・循環機能(情動と換気応答)2012

    • Author(s)
      政岡ゆり、泉崎雅彦(分担著者)
    • Total Pages
      344
    • Publisher
      真興交易
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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