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Electrophysiological analysis of autonomous function between respiration/circulation and locomotion

Research Project

Project/Area Number 24500612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionShowa University

Principal Investigator

YAZAWA Itaru  昭和大学, 医学部, 兼任講師 (40360656)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsリハビリテーション / 脳幹と脊髄の相補的機能的相互作用 / 呼吸/循環 / 歩行 / 自律機能 / 脳幹と脊髄の間の相補的機能的相互作用 / 呼吸/循環 / 呼吸・循環 / 上肢の交互運動 / 相補的機能的相互作用 / 呼吸と上肢/下肢運動の自律機能
Outline of Final Research Achievements

The interplay of neural discharge patterns involved in respiration, circulation, opening movements in the mandible, and locomotion was investigated electrophysiologically in a decerebrate and arterially perfused in situ preparation. The modulated sympathetic tone activated the forelimb pattern generator and spontaneously generated fictive locomotion. The coupling rhythm of respiration and locomotion during motion occurred. Small increases in blood pressure were always generated after the initiation of motion. Opening movements in the mandible, occurring during the inspiratory (I) phase, were generated in both the I and expiratory (E) phases during motion. The activated cervical cord producing locomotion contributed to generating the opening movement in the mandible in the E phase during motion. These results suggest that this reciprocal functional interaction between the brainstem and the spinal cord plays an important role in increasing oxygenated blood flow during locomotion.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (11 results)

  • [Journal Article] Effects of ouabain on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats and in decerebrate and arterially perfused in situ preparation from juvenile rats.2015

    • Author(s)
      Tsuzawa K., Yazawa I., Shakuo T., Ikeda K., Kawakami K. and Onimaru H.
    • Journal Title

      Neuroscience

      Volume: 286 Pages: 404-411

    • DOI

      10.1016/j.neuroscience.2014.12.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reciprocal functional interactions between the respiration/circulation center, the upper spinal cord, and the trigeminal system.2015

    • Author(s)
      Yazawa I. and Shioda S.
    • Journal Title

      Translational Neuroscience

      Volume: 6 Issue: 1 Pages: 87-102

    • DOI

      10.1515/tnsci-2015-0008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Transcription factor IRF8 activates integrin-mediated TGFβ signaling and promotes neuroinflammation.2014

    • Author(s)
      Yoshida Y., Yoshimi R., Yoshii H., Kim D., Dey A., Xiong H., Munasinghe J., Yazawa I., O’Donovan MJ., Maximova O., Sharma S., Zhu J., Wang H., Morse III HC. and Ozato K.
    • Journal Title

      Immunity

      Volume: 40 Issue: 2 Pages: 1-12

    • DOI

      10.1016/j.immuni.2013.11.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal functional interactions between the brainstem and the lower spinal cord.2014

    • Author(s)
      Yazawa I.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 8 Pages: 124-124

    • DOI

      10.3389/fnins.2014.00124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Reciprocal functional interactions between the respiration/circulation center, the upper spinal cord, and the trigeminal system.2015

    • Author(s)
      Yazawa I.
    • Organizer
      第38回日本神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of effects of eugenol on respiratory activity in the brainstem-spinal cord preparation isolated from newborn rat and in the decerebrate and arterially perfused in situ preparation from juvenile rat.2015

    • Author(s)
      Kotani S., Yazawa I. and Onimaru H.
    • Organizer
      第92回日本生理学学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reciprocal functional interactions between the respiration/circulation center, the upper spinal cord, and the trigeminal system.2014

    • Author(s)
      I. Yazawa
    • Organizer
      Society for Neuroscience 2014 Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reciprocal functional interactions between the brainstem and the lower spinal cord.2014

    • Author(s)
      Yazawa I.
    • Organizer
      第37回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lower jaw movements generated in the inspiratory phase in a decerebrate and arterially perfused in situ rat preparation.2013

    • Author(s)
      Nakayama K. Yokomatsu M., Mochizuki A., Inoue T., Yazawa I.
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Significance of Na/K ATPase on respiratory rhythm generation in the new born rat in vitro- and in the juvenile rat in situ- preparations.2013

    • Author(s)
      Onimaru H., Tsuzawa K., Tani M., Yazawa I.
    • Organizer
      第36回日本神経科学学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Switching of lower jaw’s movements between the inspiratory and expiratory phases generated by chemoreceptor inputs.2013

    • Author(s)
      Nakayama K., Yokomatsu M., Mochizuki A., Inoue T., Yazawa I.
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional interactions between the respiratory center, the upper spinal cord, and the trigeminal system.2013

    • Author(s)
      Yazawa I., Tachikawa S., Mochizuki A., Inoue T., Nakayama K.
    • Organizer
      第42回北米神経科学会
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] A decerebrated, arterially-perfused in situ rat preparation for studies of breathing, chewing, and swallowing behaviors2013

    • Author(s)
      Kiyomi Nakayama, Ayako Mochizuki, Seiji Shiota, Tomio Inoue, Yazawa Itaru
    • Organizer
      日本生理学大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Lower jaw’s movements generated in the inspiratory phase in a decerebrate and arterially perfused in situ rat preparation2013

    • Author(s)
      Kiyomi Nakayama, Mitsuru Yokomatsu, Ayako Mochizuki, Tomio Inoue, Yazawa Itaru
    • Organizer
      日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Switching of lower jaw’s movements between the inspiratory and expiratory phases generated by chemoreceptor inputs2013

    • Author(s)
      Kiyomi Nakayama, Ayako Mochizuki, Tomio Inoue, Yazawa Itaru
    • Organizer
      International Union of Physiological Sciences 2013
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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