Production of oxidized LDL during exercise in persons with spinal cord injury
| Project/Area Number |
24500748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MITSUI Toshihito 和歌山県立医科大学, みらい医療推進センター, 助教 (70564186)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIMA Fumihiro 和歌山県立医科大学, 医学部, 教授 (00227076)
NAKAMURA Ken 和歌山県立医科大学, 医学部, 准教授 (80299635)
ITO Tomoyuki 和歌山県立医科大学, みらい医療推進センター, 講師 (90305566)
MABUCHI Hiroyuki 和歌山県立医科大学, みらい医療推進センター, 研究員 (50365508)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 障害者スポーツ / 酸化LDL / 脊髄損傷 / 車いすマラソン / 障がい者スポーツ / アドレナリン / 抗酸化 / 運動負荷 |
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| Outline of Final Research Achievements |
In persons with cervical spinal cord injury (CSCI), adrenalin secretion during exercise is absent due to a loss of sympathetic nervous control for adrenal medulla, while it’s intact in persons with lumbar spinal cord injury (LSCI). We hypothesized that a loss of adrenalin secretion during exercise would be associated with a production of oxidized LDL. Now we observed that both of oxidized LDL and plasma adrenaline did not increase in CSCI, while both increased in LSCI. The present results suggest that no increase in oxidized LDL for CSCI is associated with the loss of adrenalin secretion and that CSCI can exercise safely until at the exercise intensity set up in the present study.
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Report
(4 results)
Research Products
(1 results)
