Effect of exercise training on sarcopenia: focused on fiber number
| Project/Area Number |
24500796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tohoku Institute of Technology |
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Principal Investigator |
MASATAKA Suwa 東北工業大学, 公私立大学の部局等, 准教授 (50464392)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サルコペニア / 筋線維数 / 老化 / 運動 / 骨格筋線維 / 骨格筋 / 加齢 / SIRT1 |
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| Outline of Final Research Achievements |
The purpose of this research was to investigate the effect of exercise training or resveratrol treatment on age-related muscle fiber loss in mice. The research demonstrated that mice aged 24 months showed significant decrease in muscle fiber number of plantaris muscle in comparison to the mice aged 3 months. Wheel running training during 3 to 24 months age significantly attenuated such decrease. On the other hand, functional overload by tenotomy of gastrocnemius tendon or resveratrol treatment did not induce such phenomenon. The results imply that long-term endurance training would attenuate the age-related fiber loss in fast-twitch muscle.
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Report
(4 results)
Research Products
(4 results)
