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3D analysis of muscle metabolism during exercise

Research Project

Project/Area Number 24500799
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionTokyo Medical University

Principal Investigator

KIME Ryotaro  東京医科大学, 医学部, 講師 (90366120)

Co-Investigator(Kenkyū-buntansha) NIWAYAMA Masatsugu  静岡大学, 電子工学研究所, 准教授 (40334958)
KATSUMURA Toshihito  東京医科大学, 医学部, 教授 (80214352)
MURASE Norio  東京医科大学, 医学部, 講師 (10317894)
OSADA Takuya  東京医科大学, 医学部, 講師 (60297281)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords筋酸素動態 / 近赤外線分光法 / 磁気共鳴分光法 / 不均一性 / エネルギー代謝 / 筋エネルギー代謝 / 膝伸展運動 / 近赤外分光法
Outline of Final Research Achievements

This study used two-dimensional 31Phosphorus Chemical Shift Imaging, to detect differences between the deep and superficial parts of the human leg muscles during dynamic knee extension exercise. The experiments were carried out with a 1.5-T superconducting magnet with a 5 inch-diameter circular sur-face coil. The subjects performed dynamic one-legged knee extension exercise in the prone position, with the transmit-receive coil placed under the right quadriceps muscles in the magnet. The subjects pulled down an elastic rubber band attached to the ankle at a frequency of 0.25, 0.5 and 1 Hz for 320 sec each. The Pi/PCr of the superficial parts was not significantly increased with increasing work rate. Compared with the superficial areas, the Pi/PCr of the deep parts was significantly higher (p < 0.05) at 1Hz. The intracellular pH showed no significant difference between the two parts.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(11 results)

All 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Regional differences in muscle energy metabolism in human muscle by 31P-chemical shift imaging2015

    • Author(s)
      Kime R, Kaneko Y, Hongo Y, Ohno Y, Sakamoto A, Katsumura T
    • Journal Title

      Advances Experimental Medicine & Biology

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Skeletal muscle deoxygenation responses during treadmill exercise in children2014

    • Author(s)
      Takagi S, Kime R, Midorikawa T, Niwayama M, Sakamoto S, Katsumura T
    • Journal Title

      Advances Experimental Medicine & Biology

      Volume: (In press) Pages: 314-316

    • DOI

      10.1007/978-1-4939-0620-8_45

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal Muscle Deoxygenation Abnormalities in Early Post-Myocardial Infarction2014

    • Author(s)
      Takagi S, Murase N, Kime R, Niwayama M, Osada T, Katsumura T.
    • Journal Title

      Med Sci Sports Exerc

      Volume: Mar 11

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Which Is the Best Indicator of Muscle Oxygen Extraction During Exercise Using NIRS?: Evidence that HHb Is Not the Candidate2013

    • Author(s)
      Kime R, Fujioka M, Osawa T, Takagi S, Niwayama M, Kaneko Y, Osada T, Murase N, Katsumura T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 789 Pages: 163-169

    • DOI

      10.1007/978-1-4614-7411-1_23

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aging affects spatial distribution of leg muscle oxygen saturation during ramp cycling exercise2013

    • Author(s)
      Takagi S, Kime R, Murase N, Watanabe T, Osada T, Niwayama M, Katsumura T.
    • Journal Title

      Adv Exp Med Biol

      Volume: 789 Pages: 157-162

    • DOI

      10.1007/978-1-4614-7411-1_22

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Regional Differences of Metabolic Response during Dynamic Incremental Exercise by 31P-CSI2015

    • Author(s)
      Kaneko Y, Kime R, Hongo Y, Ohno Y, Sakamoto A, Katsumura T
    • Organizer
      International Society of Oxygen Transport to Tissue 2015
    • Place of Presentation
      中国、武漢
    • Year and Date
      2015-07-11 – 2015-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regional differences in muscle energy metabolism in human muscle by 31P-chemical shift imaging2014

    • Author(s)
      Kime R, Kaneko Y, Hongo Y, Ohno Y, Sakamoto A, Katsumura T
    • Organizer
      International Society of Oxygen Transport to Tissue 2014
    • Place of Presentation
      イギリス、ロンドン
    • Year and Date
      2014-06-28 – 2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Noninvasive determination of the relationship between mitochondrial stimuli and O2 diffusion rate during exercise2013

    • Author(s)
      Kime R, Fujioka M, Koga S, Osawa T, Osada T, Murase N, Katsumura T
    • Organizer
      International symposium on metabolic imaging and spectroscopy
    • Place of Presentation
      ペンシルバニア大学(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] 近赤外分光法(NIRS)を用いた運動時酸素代謝2013

    • Author(s)
      木目良太郎
    • Organizer
      第3回高気圧酸素スポーツ医学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Does HHb indicate muscle O2 extraction during exercise?2012

    • Author(s)
      Kime R, Fujioka M, Osawa T, Takagi T, Niwayama M, Kaneko Y, Osada T, Murase N, Katsumura T
    • Organizer
      The system biology of exercise: cardio-respiratory and metabolic integration
    • Place of Presentation
      Leeds, UK
    • Related Report
      2012 Research-status Report
  • [Presentation] 運動時骨格筋エネルギー代謝の深さ方向分析 ―31P-CSIを用いて―2012

    • Author(s)
      木目良太郎,金子泰久,長田卓也,村瀬訓生,坂本 歩,勝村俊仁
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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