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Effects of chronic exercise on spatial memory in rats of neonatal hypothyroidism.

Research Project

Project/Area Number 24500805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionNakamura Gakuen College

Principal Investigator

NAKANO HIROSHI  中村学園大学, 教育学部, 准教授 (60301678)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords運動 / 甲状腺ホルモン / 空間記憶 / 記憶消去 / モリス水迷路
Outline of Final Research Achievements

The purpose of this study was to clarify whether chronic exercise after the spatial memory acquisition by aversive stimulation causes extinction of the spatial memory and changes of protein expression of brain derived neurotrophic factor (BDNF) and its receptor TrkB using rats induced hypothyroidism in the neonatal period. In normal rats, the retention of the spatial memory by Morris water maze (MWM) has been reduced after chronic running exercise, and BDNF in dorsal hippocampus has increased. In hypothyroid rat, the retention of the spatial memory by MWM has been reduced after chronic running exercise, and TrkB in the dorsal hippocampus has increased. It was suggested that chronic exercise after spatial memory acquisition by aversive stimulation would cause extinction of the spatial memory, and mechanisms of the extinction of the spatial memory in hypothyroid rats would be different from that in normal rats.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] 乳仔期の甲状腺ホルモン抑制剤投与による発達障害モデルラットにおける水迷路課題学習の性差2014

    • Author(s)
      中野裕史,池尻麻紀,岩永麻由子,中溝祐子
    • Journal Title

      中村学園大学発達支援センター研究紀要

      Volume: 5 Pages: 43-47

    • NAID

      120005724301

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軽運動で改善する発達障害モデル2013

    • Author(s)
      中野裕史
    • Journal Title

      子どもと発育発達

      Volume: 11 Pages: 157-162

    • Related Report
      2013 Research-status Report
  • [Presentation] 運動実施のタイミングが空間記憶に及ぼす影響2014

    • Author(s)
      中野裕史
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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