Studies on novel predicting factor for atherosclerosis in patients with diabetes
Project/Area Number |
24500847
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kazuto 筑波大学, 医学医療系, 講師 (30455935)
YATOH Shigeru 筑波大学, 医学医療系, 講師 (50451703)
TAKAHASHI Akimitsu 筑波大学, 医学医療系, 准教授 (70344893)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 2型糖尿病 / 冠動脈疾患 / 内膜中膜複合体厚 / 冠動脈CT / バイオマーカー / 酸化LDL / 異所性脂肪蓄積 / 心肺運動負荷試験 / 2型糖尿病 / 頸動脈内膜中膜複合体厚 / リスクスコア |
Outline of Final Research Achievements |
Diabetic macroangiopathy is a common cause of mortality in patients with diabetes. Predicting diabetic macroangiopathy is important for personalized treatmen. We studied novel predicting factors for atherosclerosis in patinets with diabetes using coronary computed tomography angiography (CCTA) and carotid maximum intima-media thickness (max-IMT). We showed that max-IMT and MDA-LDL-related variables are useful predictors for coronary artery stenosis in patietnts with type 2 diabetes.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes2015
Author(s)
Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H.
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Journal Title
Journal of diabetes research
Volume: 印刷中
Pages: 507245-507245
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes2014
Author(s)
Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 21
Issue: 8
Pages: 799-815
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 2型糖尿病患者におけるMDA-LDLを用いた脂質指標の冠動脈狭窄病変予測能の検討2013
Author(s)
藤原 和哉, 鈴木 浩明, 佐藤 明, 石津 智子, 平安座 依子, 児玉 暁, 高橋 昭光, 小林 和人, 矢藤 繁, 矢作 直也, 野牛 宏晃, 曽根 博仁, 島野 仁
Organizer
第45回日本動脈硬化学会総会・学術集会
Place of Presentation
東京
Related Report
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[Presentation] フラミンガムリスクスコア、UKPDSリスクエンジン、max-IMT、LDL/HDL比による冠動脈病変予測能に関する検討.2012
Author(s)
藤原 和哉, 鈴木 浩明, 佐藤 明, 大崎 芳典, 尾本 美代子, 豊島 晶子, 平安座 依子, 児玉 暁, 斎藤 和美, 小林 和人, 矢藤 繁, 高橋 昭光, 山田 信博, 曽根 博仁, 島野 仁
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Related Report