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New function of fat-soluble compounds for improvement of life style diseases

Research Project

Project/Area Number 24500863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionMinatogawa College (2014)
Kobe University (2013)
Kyoto Prefectural University of Medicine (2012)

Principal Investigator

ADACHI Tetsuya  湊川短期大学, その他部局等, 教授 (60345014)

Co-Investigator(Renkei-kenkyūsha) 松永 哲郎  鳴門教育大学, 講師 (10452286)
奥野 恭史  京都大学, 教授 (20283666)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGPCR / 生活習慣病 / Gタンパク共役型受容体 / シグナル伝達 / エストロゲン / 受容体 / 代謝異常疾患
Outline of Final Research Achievements

We examined the expression and function of G-protein coupled receptor (GPCR) for fat-soluble compounds in circulation and skeletal muscle system. We discovered the expression of some fat-soluble ligand receptors in heart and skeletal muscle. GPR30 is the GPCR for estrogen. Estrogen induced the phosphorylation of ERK signal cascade in primary-cultured cardiomyocyte and skeletal muscle cell line. Moreover, estrogen via GPR30 induced the proliferation and the highly-expression of several transcription factors of these cells. These results suggest that new function of G-protein coupled receptor (GPCR) for fat-soluble compounds improves for life style diseases and metabolic syndrome.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] New physiological functions of fat-soluble compounds2015

    • Author(s)
      Adachi T
    • Journal Title

      Proc Minatogawa

      Volume: 51 Pages: 55-60

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Androgen Receptor Silences Thioredoxin-interacting Protein and Competitively Inhibits Glucocorticoid Receptor-Mediated Apoptosis in Pancreatic β-Cells.2015

    • Author(s)
      Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, Izawa T, Kuwamura M, Nakano Y, Yamaji R, Inui H.
    • Journal Title

      J Cell Biochem.

      Volume: 116 Issue: 6 Pages: 998-1006

    • DOI

      10.1002/jcb.25054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells.2014

    • Author(s)
      Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R.
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 60 Pages: 291-296

    • NAID

      130004695722

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells.2014

    • Author(s)
      Matsunaga T, Li S, Adachi T, Joo E, Gu N, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 78 Issue: 5 Pages: 843-850

    • DOI

      10.1080/09168451.2014.905175

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells.2014

    • Author(s)
      Matsunaga T,Li S, Adachi T, Joo E, Gu N, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 78 Pages: 1-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrinsic left atrial histoanatomy as the basis for reentrant excitation causing atrial fibrillation/flutter in rats2013

    • Author(s)
      Matsuyama T, Tanaka H, Adachi T, Jiang Y, Ishibashi-Ueda H, Takamatsu T
    • Journal Title

      Heart Rhythm

      Volume: 10 Issue: 9 Pages: 1342-1348

    • DOI

      10.1016/j.hrthm.2013.04.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] γ-Tocotrienol attenuates TNF-α-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes.2012

    • Author(s)
      Matsunaga T, Shoji A, Gu N, Joo E, Li S, Adachi T, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
    • Journal Title

      Mol Med Rep.

      Volume: 5 Issue: 4 Pages: 905-909

    • DOI

      10.3892/mmr.2012.770

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 脂溶性物質の新しい生理機能2014

    • Author(s)
      足達哲也
    • Organizer
      日本技術士会生物工学部会研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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