Effects of antioxidant nutrient supplementation with exercise program on prevention of sarcopenia.

Research Project

Project/Area Number	24500865
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied health science
Research Institution	Otsuma Women's University
Principal Investigator	TAKANAMI Yoshikazu 大妻女子大学, 家政学部, 教授 (40206777)
Co-Investigator(Kenkyū-buntansha)	KAWAI Yukari 公益財団法人ルイ・パストゥール医学研究センター, 基礎研究部, 研究員 (80530253) AOI Wataru 京都府立大学, 生命環境科学研究科(系), 助教 (60405272) MURASE Norio 東京医科大学, 医学部, 講師 (10317894)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	介護予防 / フレイル / サルコペニア / 廃用性筋萎縮 / 酸化ストレス / 慢性炎症 / アスタキサンチン
Outline of Final Research Achievements	The purpose of this study was to elucidate the beneficial effects of antioxidant nutrient supplementation with exercise program on prevention of sarcopenia. Experiments using animal model revealed inhibitory effect of astaxanthin on disuse muscular atrophy. Astaxanthin supplementation in combination with exercise program improved physical and muscular function of elderly women despite skeletal muscle mass did not change. These results suggest that astaxanthin in combination with exercise program may be an effective measure to prevent frailty in elderly.