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Demonstration of hyper-reduction theory on mechanism of aging and diseases

Research Project

Project/Area Number 24500881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKitasato University (2014)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2012-2013)

Principal Investigator

SASAKI Toru  北里大学, 医療衛生学部, 准教授 (30158927)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords分子イメージング / 酸化ストレス / 還元ストレス / 活性酸素 / 老化 / レドックス
Outline of Final Research Achievements

In our previous study, we found experimental results which contradict with the theory of aging that reactive oxygen species (ROS) generation increases with energy metabolism. In this study, we developed the combined apparatus, real-time bioradiography and oxygen micro-sensor in tissues slices. The ROS generation and tissue oxygen concentration were measured during hypoxia-reoxygenation using this system. ROS generation was enhanced during reoxygenation after the low oxygen supply caused hypoxic treatment. Similarly, enhanced energy demand in tissue caused hypoxia enhanced the ROS generation during reoxygenation. Low tissue oxygen concentration was confirmed in both of hypoxia models. The hypoxic condition would be cause of “hyper-reduction”, therefore the as a future study, the relationship between ROS generation and redox state in tissue is required.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Brain-specific superoxide dismutase 2 deficiency causes perinatal death with spongiform encephalopathy in mice.2014

    • Author(s)
      Izuo N, Nojiri H, Uchiyama S, Noda Y, Kawakami S, Kojima S, Sasaki T, Shirasawa T and Shimizu T
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 2014 Pages: 1-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between tissue hydroxyl radical and oxidatively modified macromolecule levels.2014

    • Author(s)
      Sasaki T, Mogi S, Kaneko T, Kojima H, Katoh S, Sano A, Kojima S
    • Journal Title

      Geriatr. Gerontol. Int.

      Volume: 14 Issue: 2 Pages: 498-507

    • DOI

      10.1111/ggi.12107

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality.2013

    • Author(s)
      Sasaki T, Tahara S, Shinkai T, Kuramoto K, Matsumoto S, Yanabe M, Takagi S, Kondo H, Kaneko T
    • Journal Title

      Exp Gerontol.

      Volume: 48 Issue: 5 Pages: 457-463

    • DOI

      10.1016/j.exger.2013.02.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superoxide generation in different brain regions of rats during normoxia and hypoxia-reoxygenation.2012

    • Author(s)
      Sasaki, T., Yamanaka, M., and Kagami, N.
    • Journal Title

      Neurosci. Res.

      Volume: 74 Pages: 261-268

    • DOI

      10.1016/j.neures.2012.10.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 自然発症矮小ラット体脂肪および骨の加齢変化の小動物用X線CTを用いた解析2013

    • Author(s)
      佐々木徹、新海正、田原正一、倉本和直、立川靖、田中秀昭、矢鍋誠、高木勝平、金子孝夫、近藤昊
    • Organizer
      第133回日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 活性酸素の生成とエネルギー代謝との関係2012

    • Author(s)
      佐々木徹、山村文子、山中正史、加賀美信幸、茂木翔一、小島周二
    • Organizer
      第35回日本基礎老化学会
    • Place of Presentation
      津田沼
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス組織ヒドロキシルラジカルレベルの加齢変化と酸化修飾マーカーとの比較2012

    • Author(s)
      飯島遼平、茂木翔一、金子孝夫、小島遥、佐野明、小島周二、佐々木徹
    • Organizer
      第35回日本基礎老化学会
    • Place of Presentation
      津田沼
    • Related Report
      2012 Research-status Report
  • [Presentation] 組織内活性酸素イメージングと発生要因のダイナミズム解析技術開発

    • Author(s)
      佐々木徹、佐々木徹、 海野けい子、 田原正一、 金子孝夫、 岩本明憲、 坪井寿、加藤徹、 工藤寛之、 加沢エリト、渡辺恭良
    • Organizer
      第2回TOBIRA研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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