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Molecular hydrogen medicine: Possible mechanisms of hydrogen antioxidant activity

Research Project

Project/Area Number 24500882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

OHSAWA Ikuroh  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (30343586)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords水素分子 / 酸化ストレス / ミトコンドリア / 培養細胞 / 抗がん剤副作用 / マウスモデル / 細胞 / 健康長寿
Outline of Final Research Achievements

Molecular hydrogen (H2) selectively reduces toxic reactive oxygen species including hydroxyl radical and ameliorates oxidative stress-induced injuries in vivo. However, precise mechanisms underlying the remarkable effect with a small amount of H2 remain unclear. In the current study, we investigated the effect of H2 on mitochondria in cultured neuroblastoma SH-SY5Y and found that H2 enhanced mitochondrial membrane potential and cellular ATP accompanying a decrease in reduced glutathione and an increase in superoxide. Pretreatment of cells with H2 suppressed the H2O2-induced cell death, whereas posttreatment did not. An increase in antioxidative enzymes of the pretreated cells indicated the possibility that a mild stress with H2 induce an increased resistance to exacerbated oxidative stress. We propose here that H2 functions both as a radical scavenger and “a mitohormetic effector” against oxidative stress.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (40 results)

All 2015 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Invited: 7 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Stimulation of human damaged sperm motility with hydrogen molecule2015

    • Author(s)
      Nakata K, Yamashita N, Noda Y, Ohsawa I
    • Journal Title

      Med Gas Res

      Volume: 5 Issue: 1 Pages: 2-2

    • DOI

      10.1186/s13618-014-0023-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiple Effects of Molecular Hydrogen and its Distinct Mechanism2014

    • Author(s)
      Noda M, Fujita K, Ohsawa I, Ito M, Ohno K
    • Journal Title

      J Neurol Disord

      Volume: 2 Issue: 06 Pages: 189-189

    • DOI

      10.4172/2329-6895.1000189

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice.2014

    • Author(s)
      Nakashima Y, Ohsawa I, Nishimaki K, Kumamoto S, Maruyama I, Suzuki Y, Ohta S
    • Journal Title

      BMC Complement Altern Med

      Volume: 14 Issue: 1 Pages: 390-390

    • DOI

      10.1186/1472-6882-14-390

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral administration of inosine produces antidepressant-like effects in mice2014

    • Author(s)
      Muto J, et al.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 4199-4199

    • DOI

      10.1038/srep04199

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      BMC Genomics.

      Volume: 14(1): Issue: 1 Pages: 248-248

    • DOI

      10.1186/1471-2164-14-248

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells2013

    • Author(s)
      Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M
    • Journal Title

      Med Gas Res

      Volume: 3 Issue: 1 Pages: 6-6

    • DOI

      10.1186/2045-9912-3-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histamine H1-Receptor Antagonistic Drug Olopatadine Suppresses TSLP in Atopic Dermatitis Model Mice2013

    • Author(s)
      Higashi M, et al
    • Journal Title

      Allergology International

      Volume: 62 Issue: 1 Pages: 137-138

    • DOI

      10.2332/allergolint.12-LE-0466

    • NAID

      130004477165

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and characterisation of a novel type of human papillomavirus 160 isolated from a flat wart of an immunocompetent patient2013

    • Author(s)
      Mitsuishi T, et al
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e79592-e79592

    • DOI

      10.1371/journal.pone.0079592

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 水素分子の疾患予防・治療効果2013

    • Author(s)
      大澤郁朗
    • Journal Title

      日本透析医会雑誌

      Volume: 28 Pages: 261-267

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012

    • Author(s)
      Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, (他21名)
    • Journal Title

      J. Bone Miner Res

      Volume: 27(9) Issue: 9 Pages: 2015-2023

    • DOI

      10.1002/jbmr.1634

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経系における水素分子の抗酸化,抗炎症作用:研究の現状2012

    • Author(s)
      大澤郁朗
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 1320-1321

    • Related Report
      2012 Research-status Report
  • [Journal Article] 水素分子の生理作用と水素水による疾患防御2012

    • Author(s)
      大澤郁朗
    • Journal Title

      日本老年医学会雑誌

      Volume: 35 Pages: 680-688

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Hydrogen water inhibits gefitinib-induced lung injury by anti-inflammatory effects2015

    • Author(s)
      Masumi Iketani, Kozue Tonaki, Tetsuya Suzuki, Jumi Ohshiro, Yasuhiro Terasaki, Mayumi Takahashi, Hideo Kawaguchi, Seisuke Hattori, Ikuroh Ohsawa
    • Organizer
      第5回分子状水素医学シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Physiological isotope effects of deuterium2015

    • Author(s)
      Maki Shibata, Kensi Koide, Mayumi Takahashi, Masumi Iketani, Hideo Kawaguchi, Ikuroh Ohsawa
    • Organizer
      第5回分子状水素医学シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 水素分子による生体機能制御2015

    • Author(s)
      大澤郁朗
    • Organizer
      第27回代用臓器再生医学研究会
    • Place of Presentation
      札幌
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 水素分子による障害精子の運動能改善2015

    • Author(s)
      大澤郁朗、野田義博、中田久美子、池谷真澄
    • Organizer
      第4回TOBIRA研究交流フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2015-02-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 水素分子のミトホルミシス効果と精子機能改善2014

    • Author(s)
      大澤郁朗、中田久美子、野田義博、村上弥生
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子状水素は活性酸素によるマウス精子運動能低下を改善する2014

    • Author(s)
      野田義博、中田久美子、倉本和直、遠藤玉夫、山下直樹、大澤郁朗
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-24 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 水素含有胚融解液はヒト凍結胚盤胞の生存能を向上させるか? -水素分子をヒト胚に用いた初の試み-2014

    • Author(s)
      中田久美子、中山順樹、池上加代子、中西彩、阿部睦、渡邊ひとみ、山下直樹、大澤郁朗
    • Organizer
      第32回日本受精着床学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-31 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 水素分子処置によるヒト不動精子の運動性回復2014

    • Author(s)
      中田久美子,山下直樹,大澤郁朗
    • Organizer
      第55回日本卵子学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-05-17 – 2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子状水素は活性酸素によるマウス精子前進性運動機能低下を抑制する2014

    • Author(s)
      野田義博、中田久美子、倉本和直、遠藤玉夫、山下直樹、大澤郁朗
    • Organizer
      第55回日本卵子学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-05-17 – 2014-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性酸素障害の新たな防御法2014

    • Author(s)
      大澤郁朗
    • Organizer
      第54回日本呼吸器学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高濃度水素水によるゲフィチニブの急性肺傷害抑制2014

    • Author(s)
      寺崎泰弘、大澤郁朗、鈴木徹也、渡名喜梢、漆山博和、寺崎美佳、功刀しのぶ、福田悠、清水章
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子状水素による神経疾患の予防と治療2014

    • Author(s)
      大澤郁朗
    • Organizer
      第10回認知症サプリメント研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高濃度重水素含有水による炎症抑制効果の検討2014

    • Author(s)
      小出賢志、村上弥生、高橋真由美、川口英夫、大澤郁朗
    • Organizer
      第4回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 高濃度水素水はゲフィチニブの薬効を阻害することなく急性肺障害を抑制する2014

    • Author(s)
      渡名喜梢、鈴木徹也、寺崎泰弘、村上弥生、高橋真由美、川口英夫、大澤郁朗
    • Organizer
      第4回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 高濃度水素水によるゲフィチニブの急性肺傷害抑制2013

    • Author(s)
      鈴木徹也、寺崎泰弘、渡名喜梢、大澤郁朗
    • Organizer
      日本基礎老化学会第36回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Overview on new medical gases: molecular hydrogen medicine for neuroprotection and slow aging2013

    • Author(s)
      Ohsawa I
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 水素分子処置によるヒト不動精子の運動性回復2013

    • Author(s)
      中田久美子,山下直樹,大澤郁朗
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 加齢に伴うマウス脳ミトコンドリア機能の低下は水溶性コエンザイムQ10飲水投与により回復する2013

    • Author(s)
      高橋真由美、大澤郁朗、高橋和秀
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Molecular hydrogen as a radioprotector: Possible mechanisms of hydrogen antioxidant activity2013

    • Author(s)
      大澤郁朗
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Molecular Hydrogen Medicine: Possible Mechanisms of Hydrogen Antioxidant Activity2012

    • Author(s)
      Ohsawa I, Murakami Y, Aoki S, Tanaka M
    • Organizer
      Annual Conference of the Korean Society for Gerontology, the 12th Korea-Japan Joint symposia
    • Place of Presentation
      Osong, Republic of Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 分子状水素による酸化ストレス抑制の分子機構2012

    • Author(s)
      大澤郁朗、村上弥生
    • Organizer
      日本基礎老化学会第35回大会
    • Place of Presentation
      船橋
    • Related Report
      2012 Research-status Report
  • [Presentation] 水素医学の現状と展望2012

    • Author(s)
      大澤郁朗
    • Organizer
      第12回抗加齢医学の実際
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 水素分子による酸化ストレス防御の分子機構2012

    • Author(s)
      大澤郁朗、村上弥生
    • Organizer
      第12回日本ミトコンドリア学会年会
    • Place of Presentation
      筑波
    • Related Report
      2012 Research-status Report
  • [Book] 医療ガス情報ファイル2013

    • Author(s)
      大澤郁朗
    • Total Pages
      36
    • Publisher
      住友精化株式会社
    • Related Report
      2013 Research-status Report
  • [Remarks] 生体環境応答研究

    • URL

      http://www.tmghig.jp/J_TMIG/kenkyu/team/seitaikankyooutou.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 生体環境応答研究

    • URL

      http://www.tmghig.jp/J_TMIG/kenkyu/team/seitaikankyooutou.html

    • Related Report
      2013 Research-status Report
  • [Remarks] Biological Process of Aging

    • URL

      http://www.tmig.or.jp/research/DA24.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 環境老化研究

    • URL

      http://www.tmghig.jp/J_TMIG/j_research/DA24.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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