Molecular hydrogen medicine: Possible mechanisms of hydrogen antioxidant activity
| Project/Area Number |
24500882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
OHSAWA Ikuroh 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 水素分子 / 酸化ストレス / ミトコンドリア / 培養細胞 / 抗がん剤副作用 / マウスモデル / 細胞 / 健康長寿 |
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| Outline of Final Research Achievements |
Molecular hydrogen (H2) selectively reduces toxic reactive oxygen species including hydroxyl radical and ameliorates oxidative stress-induced injuries in vivo. However, precise mechanisms underlying the remarkable effect with a small amount of H2 remain unclear. In the current study, we investigated the effect of H2 on mitochondria in cultured neuroblastoma SH-SY5Y and found that H2 enhanced mitochondrial membrane potential and cellular ATP accompanying a decrease in reduced glutathione and an increase in superoxide. Pretreatment of cells with H2 suppressed the H2O2-induced cell death, whereas posttreatment did not. An increase in antioxidative enzymes of the pretreated cells indicated the possibility that a mild stress with H2 induce an increased resistance to exacerbated oxidative stress. We propose here that H2 functions both as a radical scavenger and “a mitohormetic effector” against oxidative stress.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013
Author(s)
Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
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Journal Title
Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
Volume: 14(1):
Pages: 1-15
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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