Immunopotentiating activity of xanthan gum polysaccharide widely using as food thickening agent

• Project/Area Number: 24500945
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kagawa University
• Principal Investigator: OKAZAKI Katsuichiro 香川大学, 農学部, 教授 (60109733)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 食品 / 多糖 / 免疫機能 / マクロファージ / 細胞性免疫 / 乳酸菌 / 免疫学 / 糖鎖 / アレルギー・喘息

Outline of Final Research Achievements

Xanthan gum is a polysaccharide produced by Xanthomonas campestris and widely used as food thickening agent. We examined cytokine productions in mouse macrophage-like cell line (J774.1) and in mouse primary spleen cells by xanthan gum. The production of interleukin (IL)-12 in J774.1 cells was enhanced by xanthan gum. In primary spleen cells from C3H/HeN [sensitive to lipopolysaccharide (LPS)] mice, the productions of IL-12 and interferon-γ were enhanced by xanthan gum, LPS and heat-killed Lactobacillus plantarum. These results suggested that xanthan gum induces cell-mediated immune response promoted by T helper 1 type cells. Therefore, xanthan gum as well as lactic acid bacterium has also function to protect decrease of cellular immunity in aging.

Research Products

• [Journal Article] The involvement of O-antigen polysaccharide in lipopolysaccharide in macrophage activation. (2012)
  • Author(s): Shimada, M., Kadowaki, T., Taniguchi, Y., Inagawa, H., Okazaki, K. and Soma, G.
  • Journal Title: Anticancer Research Volume: 32 Pages: 2337-2342
  • Peer Reviewed
• [Presentation] 微生物多糖キサンタンガムの免疫賦活化作用と美白作用 (2015)
  • Author(s): 岡崎勝一郎、遠藤有希子、村川春菜、若松久人、奥谷康一
  • Organizer: 第17回マリンバイオテクノロジー学会大会
  • Place of Presentation: 東京海洋大学（東京都品川区）
  • Year and Date: 2015-05-30 – 2015-05-31
• [Presentation] Inhibitory mechanism of melanin biosynthesis by marine bacterial glycosaminoglycan (2012)
  • Author(s): Okazaki, K. and Okutani, K.
  • Organizer: The 9th Asia-Pacific Marine Biotechnology (第９回アジア－太平洋マリンバイオテクノロジー会議)
  • Place of Presentation: カルポート高知
• [Presentation] 海洋細菌多糖ウミノグリカンと食品増粘多糖キサンタンガムの免疫賦活作用と美白作用
  • Author(s): 岡崎勝一郎
  • Organizer: 平成25年度かがわ糖質バイオフォーラム複合糖質・糖鎖研究会
  • Place of Presentation: サンポートホール高松
  • Invited
• [Presentation] 海洋細菌多糖と希少糖の機能性及びそれらを利用した食品等の開発.
  • Author(s): 岡崎勝一郎
  • Organizer: 岡山県食品新技術応用研究会
  • Place of Presentation: テクノサポート岡山
  • Invited
• [Presentation] 海苔多糖ポルフィランの免疫賦活化作用と腸管保護作用
  • Author(s): 岡崎勝一郎
  • Organizer: かがわ糖質バイオフォーラム複合糖質・糖鎖研究会
  • Place of Presentation: サンポートホール高松
  • Invited
• [Patent(Industrial Property Rights)] 皮膚の光老化抑制剤 (2013)
  • Inventor(s): 岡崎勝一郎、奥谷康一
  • Industrial Property Rights Holder: 岡崎勝一郎、奥谷康一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-003468
  • Filing Date: 2013-02-25