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Exploration of food functionality of Dioscorea japonica targeting lipid mediator

Research Project

Project/Area Number 24500948
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionOkayama Prefectural University

Principal Investigator

TOSHIKO Suzuki-Yamamoto  岡山県立大学, 保健福祉学部, 准教授 (60301313)

Co-Investigator(Renkei-kenkyūsha) INOUE Hiroyasu  奈良女子大学, 生活環境学部, 教授 (40183743)
YAMAMOTO Kei  財団法人東京都医学総合研究所, 主席研究員 (30304504)
KAWAKAMI Yuki  岡山県立大学, 保健福祉学部, 助教 (30453202)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脂質メディエーター / PGE2 / COX-2 / mPGES-1 / 炎症 / 癌 / 自然薯 / 食品機能性 / 抗炎症 / 抗腫瘍
Outline of Final Research Achievements

In this study, we investigated novel functions of Dioscorea japonica on the related enzymes synthesizing prostaglandin (PG) E2. PGE2 is one of the lipid mediators, and is involved in many pathophysiological conditions such as inflammation and tumorigenesis. Under the conditions, PGE2 is synthesized from arachidonic acid by cyclooxygenase (COX)-2 and microsomal PGE synthase (mPGES)-1. Dioscorea japonica extract (DJE) suppressed COX-2 and mPGES-1 in carcinoma A549 and Caco-2 cells, and inflammatory RAW264 cells. DJE induced cancer cells to apoptosis, and suppressed inflammatory cytokines. In mouse model of squamous cell carcinoma of the skin, Dioscorea japonica inhibited tumor formation, suppressed COX-2 and mPGES-1, and decreased subepidermal eosinophils and neutrophils. These results indicate that Dioscorea japonica may have preventive effects against inflammation and tumorigenesis via suppression of PGE2 synthesis pathway.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Acknowledgement Compliant: 2 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (36 results) (of which Invited: 1 results)

  • [Journal Article] 4.脂質メディエーター合成系をターゲットとした抗炎症・高腫瘍効果を有する食品機能性の探索.2015

    • Author(s)
      山本 登志子、津嘉山 泉、武田 泰典、目賀 拓斗、戸田 圭祐、田中 充樹.
    • Journal Title

      アサヒグループ学術振興財団 研究紀要

      Volume: 27 Pages: 7-15

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] <i>Dioscorea japonica</i> extract down-regulates prostaglandin E<sub>2</sub> synthetic pathway and induces apoptosis in lung cancer cells2014

    • Author(s)
      Suzuki-Yamamoto T, Tanaka S, Tsukayama I, Takafuji M, Hanada T, Arakawa T, Kawakami Y, Kimoto M, Takahashi Y.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 3 Pages: 162-167

    • DOI

      10.3164/jcbn.14-25

    • NAID

      130004687668

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cellular localization of 5a-reductasein the rat cerebellum.2014

    • Author(s)
      Kiyokage E, Toida K, Suzuki-Yamamoto T, Kazunori I.
    • Journal Title

      J. Chem. Neuroanat.

      Volume: 59 Pages: 8-16

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies.2014

    • Author(s)
      Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T; Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1840 Issue: 6 Pages: 1625-1633

    • DOI

      10.1016/j.bbagen.2013.12.016

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Food functionality of the diet containing Dioscorea japonica powder targeting bioactive lipid synthesis pathway2014

    • Author(s)
      Suzuki-Yamamoto T, Tanaka S, Tsukayama I, Ohmoto A, Yoshio S, Kawakami Y, Kimoto M, Takahashi Y.
    • Journal Title

      Bulletin of Faculty of Health and Welfare Science, Okayama Prefectural University

      Volume: 20 Pages: 37-44

    • NAID

      120005397778

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular localization of 5a-reductasein the rat cerebellum.2014

    • Author(s)
      Kiyokage E, Toida K, Suzuki-Yamamoto T, Kazunori I.
    • Journal Title

      J. Nurosci. Res.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dioscorea japonica extract suppresses the expression of the related enzymes synthesizing lipid mediator prostaglandin E2.2013

    • Author(s)
      Tsukayama I, Takafuji M, Tanaka S, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T.
    • Journal Title

      Ann. Nutr. Metab.

      Volume: 63 (suppl1) Pages: 1597-1597

    • Related Report
      2013 Research-status Report
  • [Journal Article] Proteomic analysis of arginine methylated proteins in rat brain.2013

    • Author(s)
      Kimoto M, Hatanaka H, Suzuki-Yamamoto T, Suzuki M, Ito A, Yokoro M, Yamashita H, Takahashi Y.
    • Journal Title

      Ann. Nutr. Metab.

      Volume: 63 (suppl1) Pages: 327-327

    • Related Report
      2013 Research-status Report
  • [Journal Article] Antiatherogenic effect of guava leaf extracts inhibiting leukocyte-type 1 12-lipoxygenase activity2012

    • Author(s)
      Yuki Kawakami, et al
    • Journal Title

      Food Chem.

      Volume: 131 Issue: 4 Pages: 1069-1075

    • DOI

      10.1016/j.foodchem.2011.10.011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Dioscorea japonica extract suppresses cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells.2015

    • Author(s)
      Keisuke Toda, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
    • Organizer
      14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2015-07-12 – 2015-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preventive effect of Dioscorea japonica on squamous cell carcinoma of the mouse skin involving down-regulation of prostaglandin E2 synthetic pathway.2015

    • Author(s)
      Izumi Tsukayama, Yasunori Takeda , Takuto Mega, Keisuke Toda, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
    • Organizer
      14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2015-07-12 – 2015-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Purification and characterization of bovine lipocalin-type prostaglandin D synthase from cow’s milk.2015

    • Author(s)
      Toshiko Suzuki-Yamamoto, Mitsuki Tanaka, Erika Kawai, Keisuke Toda, Yui Serai, Takuto Mega, Yuki Kawakami, Yoshitaka Takahashi, Kei Yamamoto, Makoto Murakami, Masumi Kimoto.
    • Organizer
      14th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases.
    • Place of Presentation
      Budapest, Hungary.
    • Year and Date
      2015-07-12 – 2015-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin.2015

    • Author(s)
      Yasunori Takeda, Izumi Tsukayama, Takuto Mega, Keisuke Toda, Mitsuki Tanaka, Yuki Kawakami, Yoshitaka Takahashi, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan.
    • Year and Date
      2015-05-14 – 2015-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dioscorea japonica extract suppresses cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells and macrophage-like RAW264 cells.2015

    • Author(s)
      Keisuke Toda, Izumi Tsukayama, Takuto Mega, Mitsuki Tanaka, Yasunori Takeda, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan.
    • Year and Date
      2015-05-14 – 2015-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dioscorea japonica suppresses COX-2 and mPGES-1 expression and has preventive effects on squamous cell carcinoma.2015

    • Author(s)
      Izumi Tsukayama, Yasunori Takeda, Kanako Nakatani, Takuto Mega, Keisuke Toda, Yuki Kawakami, Yoshitaka Takahashi, Toshiya Arakawa, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto.
    • Organizer
      6th International Conference on Phosphplipaze A2 and Lipid Medoators (PLM2015)
    • Place of Presentation
      Tokyo, Japan.
    • Year and Date
      2015-02-10 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prevention by food functionalities targeting prostaglandin E2 synthesis pathway on inflammation and carcinogenesis.2014

    • Author(s)
      Suzuki-Yamamoto, T.
    • Organizer
      The Conference on Food and Nutrition Science among Sichuan University, Nanchang University, Woosong University, and Okayama Prefectural University
    • Place of Presentation
      Chengdu, China.
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Inhibition of leukocyte-type 12-lipoxygenase activity by Chinese tea.2014

    • Author(s)
      Yoshiko Mori, Akemi Otsuki, Shuji Okochi, Kensuke Okamoto, Yuki Kawakami, Toshiko Suzuki-Yamamoto, Hideaki Tsuji, Hideyuki Ito, Ding Zhi Fang, Yoshitaka Takahashi.
    • Organizer
      The Conference on Food and Nutrition Science among Sichuan University, Nanchang University, Woosong University, and Okayama Prefectural University
    • Place of Presentation
      Chengdu, China.
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Monoclonal and single-chain antibodies neutralize biological activities of leukotriene C4 and D4.2014

    • Author(s)
      Yuki Kawakami, Mai Kinoshita, Yoshiko Mori, Shuji Okochi, Kensuke Okamoto, Sae Sasabe, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Mitsuo Fukushima, Hideaki Tsuji, Yoshitaka Takahashi.
    • Organizer
      The Conference on Food and Nutrition Science among Sichuan University, Nanchang University, Woosong University, and Okayama Prefectural University
    • Place of Presentation
      Chengdu, China.
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 40S ribosomal protein subunit 2 is a major arginine methylated protein in rat tissues.2014

    • Author(s)
      Ryosuke Morimoto, Toshiko Suzuki-Yamamoto, Sayaka Yamamoto, Nao Nomura, Yoshitaka Takahashi, Hiromi Yamashita, Masumi Kimoto.
    • Organizer
      The Conference on Food and Nutrition Science among Sichuan University, Nanchang University, Woosong University, and Okayama Prefectural University
    • Place of Presentation
      Chengdu, China.
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dioscorea japonica extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells and macrophage-like RAW 264 cells.2014

    • Author(s)
      Izumi Tsukayama, Takuto Mega, Keisuke Toda, Yasunori Takeda, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
    • Organizer
      The Conference on Food and Nutrition Science among Sichuan University, Nanchang University, Woosong University, and Okayama Prefectural University
    • Place of Presentation
      Chengdu, China.
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibitory effect of Qing Shan Lu Shui Tea on leukocyte-type 12-lipoxygenase activity.2014

    • Author(s)
      Yuki Kawakami, Akemi Otsuki, Yoshiko Mori, Hideyuki Ito, Toshiko Suzuki-Yamamoto, Hideaki Tsuji, Ding Zhi Fang, Yoshitaka Takahashi.
    • Organizer
      ISNFF2013
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Research-status Report
  • [Presentation] Preventive effect of Dioscorea japonica on squamous cell carcinoma of the skin.2014

    • Author(s)
      Toshiko Suzuki-Yamamoto, Izumi Tsukayama, Miki Takafuji, Takuto Mega, Kanako Nakatani, Yuri Wada, Sayaka Hamasaki, Makiko Suzuki, Yuki Kawakami, Yoshitaka Takahashi.
    • Organizer
      Okayama Prefectural University-Nanchang University Workshop for Food and Nutritional Sciences,
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Dioscorea japonica extract suppresses the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in lung carcinoma A549 cells and macrophage-like RAW264 cells.2014

    • Author(s)
      Izumi Tsukayama, Sayuri Tanaka, Risako Takiuchi, Miki Takafuji, Keisuke Toda, Mitsuki Tanaka, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto.
    • Organizer
      Okayama Prefectural University-Nanchang University Workshop for Food and Nutritional Sciences,
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Inhibitory effect of tea extracts on leukocyte-type 12-lipoxygenase activity.2014

    • Author(s)
      Yuki Kawakami, Akemi Otsuki, Mai Kinoshita, Yoshiko Mori, Makiko Suzuki, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Hideaki Tsuji, Hiromi Yamashita, Hideyuki Ito, Ding Zhi Fang, Yoshitaka Takahashi.
    • Organizer
      Okayama Prefectural University-Nanchang University Workshop for Food and Nutritional Sciences,
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 自然薯のプロスタグランジンE2合成系抑制と皮膚癌モデルにおける抗腫瘍効果.2014

    • Author(s)
      山本登志子、津嘉山泉、高藤美樹、瀧内理紗子、鈴木麻希子、荒川俊哉、川上祐生、高橋吉孝.
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Dioscorea japonica extract suppresses the expression of the related enzymes synthesizing lipid mediator prostaglandin E2.2013

    • Author(s)
      Izumi Tsukayama, Miki Takafuji, Sayuri Tanaka, Yuki Kawakami, Yoshitaka Takahashi and Toshiko Suzuki-Yamamoto.
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Proteomic Analysis of Arginine Methylated Proteins in Rat Brain.2013

    • Author(s)
      Kimoto M, Hatakenaka H, Suzuki-Yamamoto T, Suzuki M, Ito A, Yokoro M, Yamashita H, Takahashi Y.
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Dioscorea japonica extract suppresses COX-2 and mPGES-1 expression and has preventive effects against squamous cell carcinoma.2013

    • Author(s)
      Toshiko Suzuki-Yamamoto, Izumi Tsukayama, Miki Takafuji, Sayuri Tanaka, Yuki Kawakami, Yoshitaka Takahashi.
    • Organizer
      16th GEM/10th GERLI lipidomics meeting: from membranes to pathologies.
    • Place of Presentation
      Saint-Jean-Cap-Ferrat, France
    • Related Report
      2013 Research-status Report
  • [Presentation] 白血球型12-リポキシゲナーゼに対する中国茶葉抽出物の阻害効果.2013

    • Author(s)
      川上祐生、大槻朱美、平野詩織、木下麻衣、山本登志子、辻英明、木本眞順美、山下広美、伊東秀之、Ding Zhi Fang、高橋吉孝.
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] 部位特異的変異体を用いた抗ロイコトリエンC4単鎖抗体の抗原結合に関与するアミノ酸の同定.2013

    • Author(s)
      木下麻衣、勝原加奈子、川上祐生、山本登志子、菅原光明、堀哲哉、齊野廣道、宮野雅司、山本尚三、高橋吉孝.
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 中国茶に含まれる白血球型12-リポキシゲナーゼ阻害成分の解析.2013

    • Author(s)
      大槻朱美、森香子、森ひとみ、李鵬、川上祐生、山本登志子、辻英明、伊東秀之、方定志、高橋吉孝.
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス海馬におけるタンパク質の非対称性アルギニンメチル化に及ぼす加齢と高脂肪食の影響.2013

    • Author(s)
      鈴木麻希子,守谷智恵,山本登志子,山下広美,高橋吉孝,坪井誠二,辻英明,木本眞順美.
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス海馬におけるタンパク質の非対称性アルギニンメチル化に及ぼす加齢と高脂肪食の影響.2013

    • Author(s)
      鈴木麻希子,守谷智恵,山本登志子,山下広美,高橋吉孝,辻英明,木本眞順美.
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 自然薯抽出物によるシクロオキシゲナーゼ-2と膜結合型プロスタグランジンE合成酵素-1の発現抑制.2013

    • Author(s)
      津嘉山泉,田中小百合,高藤美樹,吉尾壯兒,川上祐生,高橋吉孝,山本登志子.
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット組織におけるアルギニンメチル化タンパク質の検索と同定.2013

    • Author(s)
      森本亮祐,大森由香子,鈴木麻希子,野村奈央,山本登志子,山下広美,高橋吉孝,木本眞順美.
    • Organizer
      第46回日本栄養・食糧学会中国・四国支部大会
    • Place of Presentation
      山口
    • Related Report
      2013 Research-status Report
  • [Presentation] 自然薯抽出物によるシクロオキシゲナーゼ-2と膜結合型プロスタグランジンE合成酵素-1の発現抑制2013

    • Author(s)
      津嘉山泉,田中小百合,高藤美樹,吉尾壯兒,川上祐生,高橋吉孝,山本登志子
    • Organizer
      第67回日本栄養食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Dioscorea japonica extract suppresses the expression of the related enzymes synthesizing lipid mediator prostaglandin E22013

    • Author(s)
      Izumi Tsukayama, Miki Takafuji, Sayuri Tanaka, Yuki Kawakami, Yoshitaka Takahashi and Toshiko Suzuki-Yamamoto
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibitory effect of Chinese tea on leukocyte-type 12-lipoxygenase activity. International Conference on Biologically Active Substances2012

    • Author(s)
      Akemi Otsuki, Shiori Hirano, Mai Kinoshita, Ichika Shimoda, Yuki Kawakami, Toshiko Suzuki-Yamamoto, Hideaki Tsuji, Hideyuki Ito, Ding Zhi Fang and Yoshitaka Takahashi
    • Organizer
      International Conference on Biologically Active Substances, Bioactive Okayam BAO2012
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Dioscorea japonica extract suppresses the expression of COX-2 and prostaglandin E synthase.2012

    • Author(s)
      Izumi Tsukayama, Miki Takayama, Sayuri Tanaka, Yuki Kawakami, Yoshitaka Takahashi and Toshiko Suzuki-Yamamoto.
    • Organizer
      International Conference on Biologically Active Substances, Bioactive Okayam BAO2012
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] 中国茶に含まれる白血球型12-リポキシゲナーゼ阻害成分の解析.2012

    • Author(s)
      川上祐生、大槻朱美、平野詩織、木下麻衣、下田一花、山本登志子、辻英明、木本眞順美、伊東秀之、Ding Zhi Fang、高橋吉孝
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ロイコトリエン単鎖抗体を利用した炎症性疾患治療薬の開発を目指した研究.

    • Author(s)
      木下麻衣,大槻朱美,森香子,勝原加奈子,川上祐生,山本登志子,高橋吉孝.
    • Organizer
      第43回おかやまバイオアクティブシンポジウム 2013.
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 白血球型12-リポキシゲナーゼを阻害する新規化合物の解明.

    • Author(s)
      大槻朱美,森香子,木下麻衣,勝原加奈子,森ひとみ,李鵬,川上祐生,山本登志子,辻英明,伊東秀之,Ding Zhi Fang,高橋吉孝.
    • Organizer
      第43回おかやまバイオアクティブシンポジウム 2013.
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 自然薯抽出物のプロスタグランジンE2合成系抑制による抗炎症・抗腫瘍効果.

    • Author(s)
      津嘉山泉、田中小百合、高藤美樹、瀧内理紗子、川上祐生、高橋吉孝、山本登志子.
    • Organizer
      第44回おかやまバイオアクティブシンポジウム 2013.
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規モノテルペン配糖体による白血球型 12-リポキシゲナーゼ阻害.

    • Author(s)
      川上祐生,大槻朱美,森香子,伊東秀之,山本登志子,辻 英,DingZhiFang,高橋吉孝.
    • Organizer
      52 回日本油化学会年会 2013
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒドロペルオキシ基を持つ新規モノテルペン配糖体による白血球型12-リポキシゲナーゼの阻害.

    • Author(s)
      川上祐生、大槻朱美、木下麻衣、森香子、山本登志子、辻英明、伊東秀之、FANG Ding Zhi、高橋吉孝.
    • Organizer
      日本過酸化脂質・抗酸化物質学会 第21回年会.
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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