Research Project
Grant-in-Aid for Scientific Research (C)
To investigate the novel mechanism involved in oxidative stress-mediated diabetic angiopathy, we focused on function of the glutathione (GSH) redox cycle in endothelial cells. In diabetes model human umbilical vein endothelial cells (HUVEC) of the living state, the H2O2 scavenging activity via the GSH cycle was significantly reduced. We have carried out the synthesis of the causative agent. Although the synthetic compound was initially unstable, it was possible to obtain a final stable compound at a high purity. We found that this compound inhibits the H2O2 scavenging enzyme. As a protective factor of diabetic angiopathy, we found that myricetin, a food ingredient, inhibits apoptosis in diabetes model HUVEC. These substances may, at least in part, be directly involved in a novel mechanism leading from hyperglycemia to develop vascular injury.
All 2015 2014 2013 2012 Other
All Journal Article (7 results) (of which Peer Reviewed: 6 results, Open Access: 3 results) Presentation (14 results) (of which Invited: 3 results) Book (4 results)
Brain
Volume: 138 Issue: 1 Pages: 53-68
10.1093/brain/awu312
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume: 59 Pages: 49-58
J. Biol. Chem.
Volume: 290 Issue: 14 Pages: 8778-8788
10.1074/jbc.m114.625053
Mol. Cell. Biol.
Volume: 34 Issue: 18 Pages: 3421-3434
10.1128/mcb.00221-14
Cell Death & Differentiation
Volume: 19 Issue: 5 Pages: 847-858
10.1038/cdd.2011.165
Free Radic Biol Med
Volume: 53 Issue: 12 Pages: 2197-2203
10.1016/j.freeradbiomed.2012.09.040
化学と生物
Volume: 50 Pages: 316-318
