|Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|Outline of Final Research Achievements
In the present study, we examined the effect of fatty acids and function of fatty acid-binding protein 5 (FABP5) in thymopoiesis, morphology and proliferation/differentiation of thymic epithelial cells through the comparison of wild-type (WT) and FABP5-knock out (KO) mice. We found that long chain-polyunsaturated fatty acids (LC-PUFAs) and rerinoic acid (RA) promotes proliferation of cultured thymic epithelial cells via FABP5 rather than the specific function of thymic epithelial cells which regulates differentiation of thymocytes.