Preparation of high concentration of sesame lignan and mechanisms of lipid lowering effects of lignans
| Project/Area Number |
24500980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ゴマリグナン / 脂質代謝改善作用 / 抗酸化活性 / セサミノール / セサミン / 脂質代謝 / 脂質代謝改善 |
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| Outline of Final Research Achievements |
Sesaminol is a sesame lignan and is present most exclusively occurring as sesaminol triglycoside in sesame seed. In previous study, we were successfully extracted large amounts of sesaminol aglycone (SA) by fermentation method. In the present study, we further examined more useful method for the isolation of individual sesame lignans, and also their biological activities such as inhibitory activities of peroxidation and pancreatic lipase. Antioxidant activity of sesaminol aglycones by DPPH radical method was as follow; SA < sesaminol < sesamine = a mixture of sasamine, sesamorin and sesaminol triglycoside. In addition, sesaminol lignan strongly inhibited pancreatic lipase activity in vitro. These data suggest that sesaminol aglycone may possess multi-functional activities in vivo.
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Report
(4 results)
Research Products
(1 results)
