| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Insulin stimulates GLUT4 vesicle recruitment from its intracellular storage site to the PM. Cysteine string protein 1 (CSP1) is a SNARE-binding protein involved in the vesicular trafficking of neurotransmitters and other exocytic processes. In this study, we found that CSP1 is involved in insulin resistance by interrupting GLUT4 vesicle docking with the PM.
The fatty acid binding protein X has reported to bind CSP1. The down-regulation of fatty acid binding protein X increases the CSP1 expression and decrease the insulin stimulated GLUT4 translocation. We are now investigating and confirming the preliminary result about the role of the fatty acid binding protein X in GLUT4 translocation and diabetes to exam the interaction with specific fatty acid and cytoskeleton and analyze the knockout mice, belonging to find the new targets of diabetes treatment.
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