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Analysis of anti-tubercular activity through immune activation by polyphenol and consideration of its effectiveness to the prevention and the treatment

Research Project

Project/Area Number 24501015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNiigata University (2014)
Sonoda Women's University (2012-2013)

Principal Investigator

OZEKI Yuriko  新潟大学, 医歯学系, 助教 (00169301)

Co-Investigator(Kenkyū-buntansha) OKA Mayuko  京都府立大学, 生命環境科学研究科(系), 准教授 (40347498)
TAMARU Aki  大阪府立公衆衛生研究所, 感染症部, 研究員 (70270767)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsポリフェノール / 結核 / マクロファージ / マイクロアレー / 結核菌 / BCG
Outline of Final Research Achievements

Tuberculosis is the world's largest infectious disease. Because of its long administration period for the treatment, tuberculosis drugs with safer and fewer side effects are required. We found that kaempferol and luteolin inhibit growth of Mycobacterium tuberculosis infected in human monocyte-derived cell line THP1 at low cytotoxic level. In order to clarify the mechanism of inhibitory effect, we conducted microarray analysis. By the treatment of kaempferol, 41 genes affected growth inhibition of M. tuberculosis infected in THP1 cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012

All Journal Article (18 results) (of which Peer Reviewed: 16 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (13 results)

  • [Journal Article] Direct detection of Mycobacterium avium in environmental water and scale samples by loop-mediated isothermal amplification.2014

    • Author(s)
      Nishiuchi Y, Tamaru A, Suzuki Y, Kitada S, Maekura R, Tateishi Y, Niki M, Ogura H, Matsumoto S.
    • Journal Title

      J Water Health

      Volume: 12 Pages: 211-219

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ntra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis2014

    • Author(s)
      Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y
    • Journal Title

      Infect. Genet. Evolu.

      Volume: 21 Pages: 476-483

    • DOI

      10.1016/j.meegid.2013.08.010

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 私達の研究 結核ワクチン開発の現状と新しい結核ワクチン開発に向けて2014

    • Author(s)
      松本壮吉、尾関百合子
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 127-134

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.2014

    • Author(s)
      Tanaka M, Mun S, Harada A, Ohkawa Y, Inagaki A, Sano S, Takahashi K, Izumi Y, Osada-Oka M, Wanibuchi H, Yamagata M, Yukimura T, Miura K, Shiota M, Iwao H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: e96785-e96785

    • DOI

      10.1371/journal.pone.0096785

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1cells2014

    • Author(s)
      Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 445 Issue: 2 Pages: 327-33

    • DOI

      10.1016/j.bbrc.2014.01.183

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG2013

    • Author(s)
      Taniguchi K, Takii T, Yamamoto S, Maeyama J, Iho S, Maruyama M, Iizuka N, Ozeki Y, Matsumoto S, Hasegawa T, Miyatake Y, Itoh S, Onozaki K.
    • Journal Title

      Immun Ageing

      Volume: 10 Issue: 1 Pages: 25-25

    • DOI

      10.1186/1742-4933-10-25

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats.2013

    • Author(s)
      Yamazaki T, Nakamura Y, Shiota M, Osada-Oka M, Fujiki H, Hanatani A, Shimada K, Miura K, Yoshiyama M, Iwao H, Izumi Y.
    • Journal Title

      J Pharmacol Sci.

      Volume: 123 Pages: 58-66

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 複数自治体をまたぐ広域的結核分子疫学の基盤構築 ─ JATA(12)-VNTR型別に基づくクラスター形成とその傾向─2013

    • Author(s)
      和田崇之、田丸亜貴、岩本朋忠、有川健太郎、 中西典子、小向潤、松本健二、長谷篤
    • Journal Title

      Kekkaku

      Volume: 88 Pages: 393-398

    • NAID

      10031162884

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] JATA(12)-VNTR型別による結核集団発生事例の 菌株異同調査2013

    • Author(s)
      田丸亜貴、和田崇之、岩本朋忠、長谷篤
    • Journal Title

      Kekkaku

      Volume: 88 Pages: 399-403

    • NAID

      10031162885

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis2013

    • Author(s)
      Osada-Oka Mayuko
    • Journal Title

      Microbiology and Immunology

      Volume: 57 Issue: 1 Pages: 30-37

    • DOI

      10.1111/j.1348-0421.2012.12005.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple multiplex PCR for the identification of Beijing family of Mycobacterium tuberculosis with a lineage-specific mutation in Rv0679c.2013

    • Author(s)
      Nakajima C, Tamaru A, Rahim Z, Poudel A, Maharjan B, Aye KS, Ling H, Hattori T, Iwamoto T, Fukushima Y, Suzuki H, Suzuki Y, Matsuba T
    • Journal Title

      J Clin Microbiol.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 結核菌感染を診断するバイオマーカー2012

    • Author(s)
      岡 真優子 尾関百合子 松本壮吉 岩尾 洋
    • Journal Title

      大阪市医学会雑誌

      Volume: 61 Pages: 81-87

    • NAID

      40019589154

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Whole-Genome Sequence of the Hypervirulent Clinical Strain Mycobacterium intracellulare M.i.198.2012

    • Author(s)
      Tateishi, Y., S. Kitada, K. Miki, R. Maekura, Y. Ogura, Y. Ozeki, Y. Nishiuchi, M. Niki, T. Hayashi, K. Hirata, K. Kobayashi, and S. Matsumoto.
    • Journal Title

      Journal of Bacteriology

      Volume: 194 Issue: 22 Pages: 6336-6336

    • DOI

      10.1128/jb.01439-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dominant Incidence of Multidrug and Extensively Drug-Resistant Specific Mycobacterium tuberculosis Clones in Osaka Prefecture, Japan.2012

    • Author(s)
      Tamaru, A., C. Nakajima, T. Wada, Y. Wang, M. Inoue, R. Kawahara, R. Maekura, Y. Ozeki, H. Ogura, K. Kobayashi, Y. Suzuki, and S. Matsumoto.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e42505-e42505

    • DOI

      10.1371/journal.pone.0042505

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria.2012

    • Author(s)
      Niki M, Niki M, Tateishi Y, Ozeki Y, Kirikae T, Lewin A, Inoue Y, Matsumoto M, Dahl JL, Ogura H, Kobayashi K, Matsumoto S
    • Journal Title

      J Biol Chem

      Volume: 287(33) Issue: 33 Pages: 27743-52

    • DOI

      10.1074/jbc.m111.333385

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチン開発の展望2012

    • Author(s)
      松本壮吉、尾関百合子、小林和夫
    • Journal Title

      臨床と微生物

      Volume: 39 Pages: 131-136

    • Related Report
      2012 Research-status Report
  • [Journal Article] Sensitivities of cipofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones : role of mutant DNA gyrase subunits in drug resistance2012

    • Author(s)
      Y.Suzuki, C.Nakajima, A Tamaru, H.Kim, et al
    • Journal Title

      International Journal of Antimicrobial Agents

      Volume: 39 Issue: 5 Pages: 435-439

    • DOI

      10.1016/j.ijantimicag.2012.01.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity of Mycobacterium avium subsp. hominissuis strains isolated from humans, pigs, and human living environment2012

    • Author(s)
      D Iwamoto T, Nakajima C, Nishiuchi Y, Kato T, Yoshida S, Nakanishi N, Tamaru A, Tamura Y, Suzuki Y, Nasu M
    • Journal Title

      Infect. Genet. Evolu

      Volume: Vol.12 Issue: 4 Pages: 846-52

    • DOI

      10.1016/j.meegid.2011.06.018

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 高グルコースによる結核菌のNO抵抗性と増殖作用2015

    • Author(s)
      岡 真優子、大西 愛、石井 美菜子、尾関 百合子、松本 壮吉、三角 和広、 市川 寛、南山 幸子
    • Organizer
      第68回 日本酸化ストレス学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-06-11 – 2015-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] The replication of intracellular mycobacteria under high concentration of glucose is independent of inducible nitric synthase expression2015

    • Author(s)
      Mayuko Osada-Oka, Yuriko Ozeki, Hiroshi Ichikawa, Yukiko Minamiyama, Sohkichi Matsumoto
    • Organizer
      12 th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Kanagawa
    • Year and Date
      2015-05-14 – 2015-05-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当所における多剤耐性結核菌の発生状況と分子疫学:2007年以降とそれ以前の比較2015

    • Author(s)
      田丸亜貴
    • Organizer
      第90回日本結核学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成人の肺結核予防を目指した、新しい結核ワクチンの開発研究2014

    • Author(s)
      尾関百合子、西山晃史、松本壮吉
    • Organizer
      中部乳酸菌研究会
    • Place of Presentation
      長野
    • Year and Date
      2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンタミネーションが原因の結核菌検査誤判定例とその対策に関する考察2014

    • Author(s)
      田丸亜貴
    • Organizer
      第73回日本公衆衛生学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Antigen 85A and mycobacterial DNA-binding protein 1 are targets of Immunoglobulin G in individuals with old tuberculosis in Japan2014

    • Author(s)
      Mayuko Osada-Oka, Yoshitaka Tateishi, Yuriko Ozeki, Seigo Kitada, Ryoji Maekura, and Sohkichi Matsumoto
    • Organizer
      The 13 th Awaji International Forum on Infection and Immunity in Nara
    • Place of Presentation
      Nara
    • Year and Date
      2014-09-08 – 2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ケニア共和国クワレ地区小学生を対象とした潜在性結核感染と寄生虫感染の関連2014

    • Author(s)
      尾関百合子、武田知芳里、岡部真裕子、井上学、岡真優子、平山幸雄、一瀬休生、小林和夫、松本壮吉
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] マクロファージの糖代謝酵素とグルコース濃度による結核菌の増殖抑制2014

    • Author(s)
      今川裕香子、岡真優子、尾関百合子、松本壮吉
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] M株の広域的分離の原因究明ー比較ゲノム解析に基づく「結核ゲノム疫学」の導入2014

    • Author(s)
      和田崇之、岩本朋忠、瀬戸順次、田丸亜貴、長谷篤、前田伸司、阿彦忠之、山本太郎
    • Organizer
      第89回日本結核病学会総会
    • Place of Presentation
      岐阜県岐阜市
    • Related Report
      2013 Research-status Report
  • [Presentation] リコンビナントBCG (rBCG)を用いた迅速スクリーニング法による抗結核薬の探索と同定2013

    • Author(s)
      尾関百合子 西内由紀子 小椋義俊 岩本朋忠 林哲也 岡真優子 仁木満美子 立石義隆 平山幸雄 松本壮吉
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 潜在性結核患者の血清中での結核菌抗原に対するイムノグロブリンg2013

    • Author(s)
      岡真優子 立石義隆 平山幸雄 尾関百合子 小林和夫 松本壮吉
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 高病原性非結核性抗酸菌臨床分離株のゲノムシークエンス2013

    • Author(s)
      立石義隆 平山幸雄 尾関百合子 西内由紀子 仁木満美子 小椋義俊 林哲也 小林和夫 松本壮吉
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] ケニア共和国における学生の結核菌感染とhookworm感染の関連2013

    • Author(s)
      井上学 岡真優子 仁木満美子 尾関百合子 一瀬休生 小林和夫 松本壮吉
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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