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The development of chrononutrition-based dietary instructions for the prevention and treatment of lifestyle-related diseases

Research Project

Project/Area Number 24501028
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

TSUZAKI Kokoro  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (80450881)

Co-Investigator(Kenkyū-buntansha) SAKANE Naoki  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究室長(予防医学) (40335443)
KOTANI Kazuhiko  自治医科大学, 医学部, 准教授 (60335510)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords時間栄養学 / 脂質代謝 / 生活習慣病 / 食事指導 / 予防医学
Outline of Final Research Achievements

We investigated the relationships among eating schedule, lipoprotein metabolisms (small dense LDL; sdLDL), and the CLOCK 3111T/C polymorphism in women with dyslipidemia. In carriers of T/T homozygotes, the area of sdLDL was slightly higher than that in carriers of the C alleles (T/C or C/C). As carriers of T/T homozygotes had breakfast earlier, their morning fasting time was shorter than carriers of the C alleles.
Interventions were performed simultaneously in rotating shift and day shift groups to assess whether the group-based lifestyle intervention affects body weight in male shift workers. There was no difference in body weight between the 2 groups before the intervention; however, weight loss was significantly smaller in the rotating shift group than that in day shift groups after the intervention.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Invited: 3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Circadian Rhythm Genes CLOCK and PER3 Polymorphisms and Morning Gastric Motility in Humans.2015

    • Author(s)
      Yamaguchi M, Kotani K, Tsuzaki K, Takagi A, Motokubota N, Komai N, Sakane, N, Moritani T, Nagai, N.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 3 Pages: e0120009-e0120009

    • DOI

      10.1371/journal.pone.0120009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sleep status and low-density lipoprotein particle size in a general Japanese female population: the MIMA study.2013

    • Author(s)
      Kotani K, Tsuzaki K, Fujiwara S, Sakane N.
    • Journal Title

      Med Princ Pract.

      Volume: 22 Issue: 5 Pages: 510-512

    • DOI

      10.1159/000346647

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-density lipoprotein size distribution can differ between subjects with alcoholic and non-alcoholic fatty liver disease2013

    • Author(s)
      Tsuzaki K, Kotani K, Fujiwara S, Sano Y, Sakane N; the Mima study group
    • Journal Title

      Clin Lab

      Volume: in press Pages: 1-1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The CLOCK 3111 T/C SNP is associated with morning gastric motility in healthy young women2012

    • Author(s)
      Yamaguchi M, Kotani K, Sakane N, Tsuzaki K, Takagi A, Wakisaka S, Moritani T, Nagai N
    • Journal Title

      Physiology & Behavior

      Volume: 107 Issue: 1 Pages: 87-91

    • DOI

      10.1016/j.physbeh.2012.06.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Correlation between the methods for high-density lipoprotein subfraction analyses: an electrophoretic method and a homogeneous assay method2015

    • Author(s)
      Kotani K, Tsuzaki K, Ito Y, Sakane N
    • Organizer
      The European Atherosclerosis Society 2015
    • Place of Presentation
      Glasgow
    • Year and Date
      2015-03-22 – 2015-03-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effect of lifestyle intervention on weight loss in male shift workers: a feasibility study2014

    • Author(s)
      Tsuzaki K, Sukino S, Kotani K, Sakane N.
    • Organizer
      The 21st Annual Meeting of Japanese Society for Chronobiology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子どもの免疫力や体力を高める身体づくり ~生活習慣を見直そう~2014

    • Author(s)
      津崎こころ
    • Organizer
      滋賀県大津市子どもの健康を考える研修会
    • Place of Presentation
      滋賀
    • Year and Date
      2014-10-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] からだのリズムは食事から ~“いつ食べる?”からはじめる時間栄養学~2014

    • Author(s)
      津崎こころ
    • Organizer
      健康アクション佐賀21県民会議
    • Place of Presentation
      佐賀
    • Year and Date
      2014-10-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 健診で空腹時血糖異常を示した交代勤務男性への電話支援による生活習慣介入効果: J-DOIT1サブ解析2014

    • Author(s)
      津崎こころ,坂根直樹,小谷和彦,岡崎研太郎,佐藤寿一,鈴木貞夫,森田智視,和生,野田 光彦,葛谷英嗣
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] “いつ食べる?”からはじめる食とからだと心のリズム~時間栄養学から生まれた早寝・早起き・朝ごはん~2014

    • Author(s)
      津崎こころ
    • Organizer
      京都府中丹地区食育・学校給食研究大会
    • Place of Presentation
      京都
    • Year and Date
      2014-08-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 「早寝、早起き、朝ごはん」の取り組み ~こどもさんさんチャレンジ~2014

    • Author(s)
      下崎ユカ ,二木佳子
    • Organizer
      第2回日本公衆衛生看護学会学術集会
    • Place of Presentation
      小田原
    • Related Report
      2013 Research-status Report
  • [Presentation] 睡眠効率がメタボリックシンドローム構成因子に及ぼす影響2013

    • Author(s)
      津崎こころ,河口八重子,鋤納心,小谷和彦,坂根直樹
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Effect of pitavastatin treatment on high-density lipoprotein subfractions by non-denaturing polyacrylamide gel electrophoresis in patients with hypercholesterolemia2013

    • Author(s)
      Tsuzaki K, Kotani K, Yamada K, Sakane N
    • Organizer
      2013 AACC annual meeting & Clinical Lab Expo 2013
    • Place of Presentation
      Houston, TX, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 生活習慣修正あるいは薬物療法における脂質プロファイル改善への効果2013

    • Author(s)
      津崎こころ、小谷和彦、山田和範、坂根直樹
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] The difference of high-density lipoprotein subfractions evaluated by non-denaturing polyacrylamide gel electrophoresis method between non-alcoholic fatty liver disease and alcoholic fatty liver disease.2012

    • Author(s)
      Tsuzaki K, Kotani K, Fujiwara S, Sakane N
    • Organizer
      American Association for Clinical Chemistry Annual meeting
    • Place of Presentation
      Los Angeles
    • Related Report
      2012 Research-status Report
  • [Presentation] 時計遺伝子多型と食事のリズムが脂質プロファイルに与える影響2012

    • Author(s)
      津崎こころ,松岡幸代,小谷和彦,坂根直樹
    • Organizer
      日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 脂質異常症者の心血管発症に及ぼす要因:糖尿病の影響2012

    • Author(s)
      津崎こころ,松岡幸代,小谷和彦,坂根直樹
    • Organizer
      日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] Nutrition Care 「外来で行われる特殊な血液検査には何があるの?」2014

    • Author(s)
      津崎こころ
    • Total Pages
      2
    • Publisher
      メディカ出版
    • Related Report
      2014 Annual Research Report
  • [Remarks] 舞鶴市教育委員会食育だより8・9号

    • URL

      http://www.city.maizuru.kyoto.jp/common/fckeditor/editor/filemanager/connectors/php/transfer.php?file=/201408/uid000071_E9A39FE882B2E381A0E38288E3828A204832362E38EFBDA539E69C88E58FB72E706466

    • Related Report
      2014 Annual Research Report
  • [Remarks] 「時間栄養学の活用 何を食べるからいつ食べるへ」

    • URL

      http://www.city.higashiosaka.lg.jp/0000010214.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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