Genomic instability by HIV-1 infection
| Project/Area Number |
24501308
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Carcinogenesis
|
|---|
| Research Institution | National Center for Global Health and Medicine |
|---|
Principal Investigator |
Shimura Mari 国立研究開発法人国立国際医療研究センター, 難治性疾患研究部, 室長 (90226267)
|
|---|
| Research Collaborator |
Matsunaga Akihiro 国立国際医療研究センター, 研究所・難治性疾患研究部・難治性疾患研究室, 上級研究員 (60623816)
|
|---|
| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | HIV-1 / ゲノム不安定性 / 染色体異常 / HIV関連リンパ腫 / HIV-1感染 / Vpr / 染色体転座 / HIV / chromosome translocation / genomic instability |
|---|
| Outline of Final Research Achievements |
The incidence of tumors in HIV-infected individuals are still high compared to non-infected population, although longevity of HIV-infected individuals had been prolonged due to the development of anti-HIV drug and therapy. Especially, B-cell lymphoma was reported as 20% of HIV-infected individuals, which is very high incidence. Therefore, we hypothesized that genomic instability might be potentially existed in HIV-infected individuals before the tumoregenesis. In this study, we found genomic instability both in experiments using cell lines and in prematured B-cell lymphocytes using clinical samples from HIV-1 patients without malignancies, suggesting potential risks of malignancy.
|
Report
(6 results)
Research Products
(10 results)
