|Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|Outline of Final Research Achievements
Cancer cells are more resistant to hypoxia than normal cells. We found that mitochondrial protein Prohibitin was decreased under hypoxic conditions, and that overexpression of Prohibitin inhibited cell death induced by hypoxia. Furthermore, Knockdown of Prohibitin in human colon cancer cells reduced S phase cell fraction and decreased cell proliferation. In addition, we analyzed functional cooperation of Prohibitin and mitochondrial protein Hint2 in colon cancer cells.