• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of molecular function of S100A14 and its clinical aplication to diagnosis and therapy of breast cancer.

Research Project

Project/Area Number 24501318
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionShizuoka Cancer Center Research Institute

Principal Investigator

SUGINO Takashi  静岡県立静岡がんセンター(研究所), その他部局等, その他 (90171165)

Co-Investigator(Renkei-kenkyūsha) TANAKA Mizuko  福島県立医科大学, 医学部, 助教 (40583638)
TOMIKAWA Naoki  福島県立医科大学, 医学部, 講師 (80468587)
CHIBA Hideki  福島県立医科大学, 医学部, 教授 (00295346)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsS100A14 / S100A16 / 乳癌 / 予後 / 浸潤 / 細胞運動 / がん転移 / 転移 / 予後因子
Outline of Final Research Achievements

S100 family proteins have recently been identified as biomarkers in various cancers. The aim of the present study was to clarify the clinical significance and functional role of S100A14 in breast cancer. Immunohistochemical analysis of 167 breast cancer cases showed that higher expression levels of the proteins was significantly associated with a poorer prognosis. In the human breast cancer cell lines, S100A14 protein was colocalized on the cell membrane. Experimental analyses demonstrated that the S100A14 protein can bind to actin. A Boyden chamber assay showed that S100A14 knockdown suppressed the invasive activity. We demonstrated that coexpression of S100A14 and S100A16 correlates with poor prognosis of breast cancer patients. In addition, our findings indicate that these proteins can promote invasive activity of breast cancer cells via an interaction with cytoskeletal dynamics.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.2015

    • Author(s)
      Tanaka M, Ichikawa-Tomikawa N, Shishito N, Nishiura K, Miura T, Hozumi A, Chiba H, Yoshida S, Ohtake T, Sugino T
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 53-53

    • DOI

      10.1186/s12885-015-1059-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immunologically augmented skin flap as a novel dendritic cell vaccine against head and neck cancer in a rat model.2015

    • Author(s)
      Inoue K, Saegusa N, Omiya M, Ashizawa T, Miyata H, Komiyama M, Iizuka A, Kume A, Sugino T, Yamaguchi K, Kiyohara Y, Nakagawa M, Akiyama Y.
    • Journal Title

      Cancer Sci.

      Volume: 106 (2) Issue: 2 Pages: 143-150

    • DOI

      10.1111/cas.12586

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of highly metastatic cell line (Lu10) from murine mammary carcinoma cell line MCH66 and biological characteristics of Lu10.2014

    • Author(s)
      Ogura G, Sugino T, Suzuki T, Nakamura N.
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 39 (2) Pages: 72-79

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line.2014

    • Author(s)
      Akiyama Y, Ashizawa T, Komiyama M, Miyata H, Oshita C, Omiya M, Iizuka A, Kume A, Sugino T, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K.
    • Journal Title

      Oncol Rep

      Volume: 32 (1) Issue: 1 Pages: 159-166

    • DOI

      10.3892/or.2014.3195

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line2014

    • Author(s)
      Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
    • Journal Title

      Int J Oncol.

      Volume: 411-8 Issue: 1 Pages: 411-418

    • DOI

      10.3892/ijo.2014.2439

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.2014

    • Author(s)
      Akiyama Y, Komiyama M, Miyata H, Yagoto M, Ashizawa T, Iizuka A, Oshita C, Kume A, Nogami M, Ito I, Watanabe R, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K.
    • Journal Title

      Oncol Rep.

      Volume: 31 Issue: 4 Pages: 1683-1690

    • DOI

      10.3892/or.2014.3049

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of an uncovered region in fibrin clots and its clinical significance.2013

    • Author(s)
      Hisada Y, Yasunaga M, Hanaoka S, Saijou S, Sugino T, Tsuji A, Saga T, Tsumoto K, Manabe S, Kuroda J, Kuratsu J, Matsumura Y.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 2604-2604

    • DOI

      10.1038/srep02604

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute lung injury with alveolar hemorrhage as adverse drug reaction related to crizotinib.2013

    • Author(s)
      Ono A, Takahashi T, Oishi T, Sugino T, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Murakami H, Nakajima T, Endo M, Yamamoto N.
    • Journal Title

      J Clin Oncol.

      Volume: 31

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potential for respiratory epithelium regeneration from induced pluripotent stem cells.2013

    • Author(s)
      Otsuki K, Imaizumi M, Nomoto Y, Wada I, Miyake M, Sugino T, Omori K.
    • Journal Title

      Ann Otol Rhinol Laryngol.

      Volume: 122 Pages: 25-32

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression.2013

    • Author(s)
      Oguro T, Ishibashi K, Sugino T, Hashimoto K, Tomita S, Takahashi N, Yanagida T, Haga N, Aikawa K, Suzutani T, Yamaguchi O, Kojima Y.
    • Journal Title

      Eur J Cancer.

      Volume: 49 Pages: 1715-1724

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Implantation site-dependent differences for tracheal regeneration with induced pluripotent stem cells (iPS cells)2013

    • Author(s)
      Imaizumi M, Omori K, et al.
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 133 Issue: 4 Pages: 405-411

    • DOI

      10.3109/00016489.2012.742566

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Use of Induced Pluripotent Stem Cells (iPSCs) for the Regeneration of Tracheal Cartilage2013

    • Author(s)
      Imaizumi M, Omori K, et al.
    • Journal Title

      Cell Transplantation

      Volume: 22 Issue: 2 Pages: 341-353

    • DOI

      10.3727/096368912x653147

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial.2012

    • Author(s)
      Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, Ashizawa T, Yagoto M, Abe Y, Mitsuya K, Watanabe R, Sugino T, Yamaguchi K, Nakasu Y.
    • Journal Title

      BMC Cancer

      Volume: 27;12 Issue: 1 Pages: 623-623

    • DOI

      10.1186/1471-2407-12-623

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A combination of liposomal sunitinib plus liposomal irinotecan and liposome co-loaded with two drugs enhanced antitumor activity in PC12-bearing mouse.2012

    • Author(s)
      Maitani Y, Saito H, Seishi Y, Iwase Y, Yamauchi T, Higashiyama K, Sugino T.
    • Journal Title

      J Drug Target

      Volume: 20(10) Issue: 10 Pages: 873-882

    • DOI

      10.3109/1061186x.2012.723215

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interphase cytogenetic analysis of lung adenocarcinomas with bronchioloalveolar pattern.2012

    • Author(s)
      Shimizu H, Sugino T, Chiba H.
    • Journal Title

      Fukushima J Med Sci.

      Volume: 58(1) Pages: 66-73

    • NAID

      130002153561

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of primary central nervous system lymphoma after open head injury2012

    • Author(s)
      Honma M, Ota M, Sato N, Ogawa K, Sugino T, Yamamoto T.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52(5) Pages: 329-335

    • NAID

      130004505261

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Malignant mixed Müllerian tumor of the fallopian tube: a case report.2012

    • Author(s)
      Watanabe T, Sugino T, Furukawa S, Soeda S, Nishiyama H, Fujimori K.
    • Journal Title

      Eur J Gynaecol Oncol.

      Volume: 33(2) Pages: 223-226

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of chromosome 19q13.42 amplification in embryonal tumors2012

    • Author(s)
      Nobusawa-S, Yokoo-H, et al.
    • Journal Title

      Brain Pathol

      Volume: (in press) Issue: 5 Pages: 689-697

    • DOI

      10.1111/j.1750-3639.2012.00574.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of IL1-beta by ovarian cancer cells induces mesothelial cell beta1-integrin expression facilitating peritoneal dissemination.2012

    • Author(s)
      Watanabe T, Hashimoto T, Sugino T, Soeda S, Nishiyama H, Morimura Y, Yamada H, Goodison S, Fujimori K.
    • Journal Title

      J Ovarian Res

      Volume: 5(1) Issue: 1 Pages: 7-7

    • DOI

      10.1186/1757-2215-5-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Expression of S100A14 promotes cancer cell invasion and metastasis and is associated with poor prognosis in breast cancer2014

    • Author(s)
      Takashi Sugino, Mizuko Tanaka, Takuma Oishi and Takashi Nakajima
    • Organizer
      37th Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2014-12-09 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス転移モデルの作製とmicroarray, in vivo knockdownを用いた転移関連分子の同定

    • Author(s)
      杉野隆、千葉英樹、中島孝
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス乳癌転移モデルの開発と転移関連遺伝子の探索

    • Author(s)
      宍戸奈美子、田中瑞子、冨川直樹、千葉英樹、杉野隆
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2023-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi