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The examination of the initial change and therapeutic effects using molecular targeted agents for advanced renal cell carcinoma

Research Project

Project/Area Number 24501350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical oncology
Research InstitutionNagoya University

Principal Investigator

SASSA Naoto  名古屋大学, 医学部附属病院, 助教 (50437026)

Co-Investigator(Kenkyū-buntansha) GOTOH Momokazu  名古屋大学, 大学院医学系研究科, 教授 (10186900)
YAMAMOTO Tokunori  名古屋大学, 大学院医学系研究科, 准教授 (20182636)
服部 良平  名古屋大学, 医学(系)研究科(研究院), 准教授 (20324410)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords腎細胞癌 / 分子標的剤 / 化学療法 / 血管内皮細胞密度 / VEGF阻害剤 / 術前補助療法 / 転移性腎細胞癌 / L-FABP / 進行性腎細胞癌 / 腫瘍血流 / FABP / ダイナミックCT / スニチニブ / ソラフェニブ / TKI / 腎細胞がん / 腫瘍血流評価
Outline of Final Research Achievements

For advanced renal cell carcinoma, we conducted a study to determine the therapeutic effect of the molecular target agent earlier. Molecular targeting agentexerts a therapeutic effect by inhibiting tumor blood flow, it was revealed in our study. By determining therapeutic effect earlier, the patients avoided that suffer from excessive side effects, and also can receive more appropriate treatment. In addition, the drug, why cure is obtained from not, still the all tumor blood vessels it clear that it is difficult to destroyer in drug, it hopes will lead to the development of future research.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Presurgical/Neoadjuvant Therapy for Advanced Renal Cell Carcinoma with Molecular target Agents in Nagoya University2013

    • Author(s)
      佐々直人
    • Journal Title

      泌尿器外科

      Volume: 26 Pages: 45-47

    • Related Report
      2013 Research-status Report
  • [Journal Article] Is pT3 urothelial carcinoma of the renal pelvis a homogeneous disease entity? Proposal for a new subcategory of the pT3 classification.2012

    • Author(s)
      Sassa N, Tsuzuki T, Fukatsu A, Majima T, Kimura T, Nishikimi T, Yoshino Y, Hattori R, Gotoh M.
    • Journal Title

      Histopathology.

      Volume: 61(4) Pages: 620-628

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re: Shahrokh F. Shariat, Richard Zigeuner, Michael Rink, et al. Subclassification of pT3 urothelial carcinoma of the renal pelvicalyceal system is associated with recurrence-free and cancer-specific survival: proposal for a revision of the current TNM classification.2012

    • Author(s)
      Tsuzuki T, Sassa N, Gotoh M.
    • Journal Title

      european urology

      Volume: 61(6) Issue: 6 Pages: e61-e61

    • DOI

      10.1016/j.eururo.2012.03.033

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of warm ischemia on renal function during partial nephrectomy: assessment with new 99mTc-mercaptoacetyltriglycine scintigraphy parameter.2012

    • Author(s)
      Funahashi Yasuhito
    • Journal Title

      Urology

      Volume: 79(1) Issue: 1 Pages: 160-164

    • DOI

      10.1016/j.urology.2011.08.071

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 腎盂癌における術前画像ステージングの可能性-造影CTによる予後良港、不良群の鑑別は可能か-

    • Author(s)
      佐々直人
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] The evaluation of new pathological prognostic factor in urothelial carcinoma is the prognosis of pathological T3 differnt between renal pelvis and ureter tumor

    • Author(s)
      N Sassa
    • Organizer
      32th Congress of the Societe International d Urologie
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Research-status Report
  • [Presentation] TKI治療後の腎癌の病理学的変化 TKIの作用機序は

    • Author(s)
      都築豊徳、佐々直人
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 名古屋大学における術前分子標的剤投与を施行した腎細胞がん症例の検討

    • Author(s)
      佐々直人
    • Organizer
      第43回腎癌研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] YEAR BOOK of RCC 20112012

    • Author(s)
      佐々直人、服部良平、後藤百万
    • Total Pages
      217
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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