| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
It has been demonstrated that laminin binding activity of α-dystroglycan (α-DG) is reduced in many cancer cells by the defective glycosylation of α-DG and glycosyltransferase LARGE hyperglycosylates and increases its laminin binding activity. In this study, we investigated possible therapeutic strategy for cancer using LARGE. We demonstrated that, in addition to the increment of laminin binding activity, LARGE suppresses proliferation and invasion of cancer cells by modulating gene expression pattern involved in them. However, overexpression of LARGE inhibited differentiation of non-cancer cells, such as myoblasts. Therefore, further experiments are necessary to apply LARGE for the cancer therapy.
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