Nutrition and molecular genetic epidemiology analysis of prostate cancer
Project/Area Number |
24501364
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cancer epidemiology and prevention
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Research Institution | Kumamoto University |
Principal Investigator |
KATOH Takahiko 熊本大学, 大学院生命科学研究部, 教授 (70169506)
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Co-Investigator(Renkei-kenkyūsha) |
YAMANO Yuko 昭和大学, 医学部, 准教授 (30167580)
TAKAHASHI Hiroyuki 慈恵会医科大学, 医学部, 准教授 (00246414)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 前立腺がん / 分子疫学 / 栄養学 / 予防医学 / 遺伝子多型 / 食物摂取頻度調査 / ライフスタイル / 遺伝子検査 / 予防医療 |
Outline of Final Research Achievements |
We conducted a comprehensive epidemiological analysis of genetic and environmental factors to clarify the risk factors for prostate cancer (PCa) in Japanese nationals. Result: 1) There are no significant increased risks of PCa on quantified nutrients at present. 2) Estrogen receptor 2 (ESR2) rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR= 0.68, 95% CI, 0.47-0.97, P < 0.05 and AG + AA: OR= 0.67, 95% CI, 0.47-0.94, P< 0.05). When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR= 0.48, 95% CI, 0.25-0.95, P< 0.05) and ESR2 rs4986938 AG + AA genotype (OR= 0.64, 95% CI, 0.41-1.00, P< 0.05) showed significantly decreased PCa risk in the ever-smoker group.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012
Author(s)
Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T et al.
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Journal Title
Nature Genetics
Volume: 44
Pages: 426-429
DOI
Related Report
Peer Reviewed
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