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Effect and risk evaluation of the exposure to air pollution during pregnancy for increasing prevalence of allergic diseases in future generation

Research Project

Project/Area Number 24510035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment/Environmental policy
Research InstitutionNara Medical University

Principal Investigator

HAMADA Kaoru  奈良県立医科大学, 医学部, 教授 (80228535)

Co-Investigator(Kenkyū-buntansha) SHO Masayuki  奈良県立医科大学, 医学部, 准教授 (50364063)
SUZAKI Yasue  奈良県立医科大学, 医学部, 講師 (30382302)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords気管支喘息 / 大気汚染粉塵 / 喫煙 / 次世代影響評価 / エピジェネティクス / Th2サイトカイン / 大気汚染 / 環境影響評価 / ディーゼル燃焼灰燼 / 石油燃焼灰燼
Outline of Final Research Achievements

Prevalence of allergic disease is increasing. Tobacco smoking during pregnancy can contribute to development of asthma in the offspring. Actually neonatal mice from mothers exposed to pollutants before delivery could express asthma manifestation easily. As the mechanism(s), these mice showed the persistent Th2-dominant immune profile after birth. RT-PCR study with neonatal splenic cells revealed reduced immunoexpression of regulatory T cell suggesting activated immune systems by prenatal exposure In addition, increased gene expression of a histone-deacetylase and a histone methylransferase in splenic lymphocytes indicated contribution of epigenetics mechanism.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] Over-generation effects of cigarette smoking during pregnancy prmote allergic susceptibility2015

    • Author(s)
      K. Hamada、T. Ito、M.Sho、Y. Suzaki
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      米国ボストン市
    • Year and Date
      2015-03-29 – 2015-04-01
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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