Development of zebrafish-based assay to detect developmental neurotoxicity of irradiation and to identify protectants against the neurotoxicity
| Project/Area Number |
24510069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Mie University |
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Principal Investigator |
NISHIMURA Yuhei 三重大学, 医学(系)研究科(研究院), 准教授 (30303720)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshio 三重大学, 大学院医学系研究科, 教授 (00135443)
SHIMADA Yasuhito 三重大学, 大学院医学系研究科, 助教 (40378427)
UMEMOTO Noriko 三重大学, 大学院医学系研究科, 助教 (40649365)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線 / 発達神経毒性 / 行動解析 / 治療薬 / スクリーニング / ゼブラフィッシュ / 放射線影響評価 / 蛍光生体イメージング |
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| Outline of Final Research Achievements |
The developing brain is extremely sensitive to irradiation. Irradiation during development has been implicated in various neuropsychiatric and neurological disorders. In this study, we were able to develop zebrafish-based behavior assay to detect subtle but significant developmental neurotoxicity of irradiation and to identify chemicals protective to the developmental neurotoxicity of irradiation.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models.2013
Author(s)
Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T.
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Journal Title
ACS Chem Neurosci
Volume: 4
Pages: 1183-1193
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.2012
Author(s)
Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T.
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Journal Title
BMC Neuroscience
Volume: 13
Pages: 101-101
DOI
Related Report
Peer Reviewed
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