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Development of zebrafish-based assay to detect developmental neurotoxicity of irradiation and to identify protectants against the neurotoxicity

Research Project

Project/Area Number 24510069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionMie University

Principal Investigator

NISHIMURA Yuhei  三重大学, 医学(系)研究科(研究院), 准教授 (30303720)

Co-Investigator(Kenkyū-buntansha) TANAKA Toshio  三重大学, 大学院医学系研究科, 教授 (00135443)
SHIMADA Yasuhito  三重大学, 大学院医学系研究科, 助教 (40378427)
UMEMOTO Noriko  三重大学, 大学院医学系研究科, 助教 (40649365)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords放射線 / 発達神経毒性 / 行動解析 / 治療薬 / スクリーニング / ゼブラフィッシュ / 放射線影響評価 / 蛍光生体イメージング
Outline of Final Research Achievements

The developing brain is extremely sensitive to irradiation. Irradiation during development has been implicated in various neuropsychiatric and neurological disorders. In this study, we were able to develop zebrafish-based behavior assay to detect subtle but significant developmental neurotoxicity of irradiation and to identify chemicals protective to the developmental neurotoxicity of irradiation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 7 results) Remarks (1 results)

  • [Journal Article] Zebrafish as a systems toxicology model for developmental neurotoxicity testing.2015

    • Author(s)
      Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
    • Journal Title

      Congenit Anom (Kyoto).

      Volume: 55 Issue: 1 Pages: 1-16

    • DOI

      10.1111/cga.12079

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion.2014

    • Author(s)
      Yata K, Nishimura Y, Unekawa M, Tomita Y, Suzuki N, Tanaka T, Mizoguchi A, Tomimoto H.
    • Journal Title

      Stroke.

      Volume: 45 Issue: 12 Pages: 3698-3703

    • DOI

      10.1161/strokeaha.114.005891

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models.2013

    • Author(s)
      Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T.
    • Journal Title

      ACS Chem Neurosci.

      Volume: 4 Issue: 8 Pages: 1183-1193

    • DOI

      10.1021/cn400010t

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.2012

    • Author(s)
      Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T.
    • Journal Title

      BMC Neuroscience

      Volume: 13 Issue: 1 Pages: 101-101

    • DOI

      10.1186/1471-2202-13-101

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ゼブラフィッシュを用いた創薬スクリーニング2015

    • Author(s)
      西村有平、川瀬玲子、田中利男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Systems Pharmacology for Retinal Diseases2015

    • Author(s)
      Nishimura Y, Kawase R, Tanaka T
    • Organizer
      The 88th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュによる新しい網膜保護機構解析2014

    • Author(s)
      西村有平、梅本紀子、田中利男
    • Organizer
      第34回日本眼薬理学会年会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2014-09-13 – 2014-09-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] バルプロ酸による催奇形性のシステムズ薬理学2014

    • Author(s)
      村上宗一郎、西村有平、笹川翔太、芦川芳史、川端美湖、張貝貝、島田康人、梅本紀子、田中利男
    • Organizer
      第54回日本先天異常学会学術年会
    • Place of Presentation
      麻布大学
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺伝子改変ゼブラフィッシュを用いたニコチンの発達神経毒性評価2014

    • Author(s)
      西村有平、村上宗一郎、芦川芳史、笹川翔太、川端美湖、梅本紀子、有吉美稚子、張貝貝、島田康人、田中利男
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゼブラフィッシュによる医薬品の生殖発生毒性評価2014

    • Author(s)
      西村有平、田中利男、島田康人、梅本紀子
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュを用いたBBB機能イメージング2014

    • Author(s)
      西村有平、梅本紀子、田中利男
    • Organizer
      第9回トランスポーター研究会年会
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] In vivo fluorescent imaging of blood-brain barrier disruption in zebrafish using a novel dye.2014

    • Author(s)
      Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T.
    • Organizer
      DNT4
    • Place of Presentation
      The Inn at Penn, Philadelphia, PA
    • Year and Date
      2014-05-11 – 2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Novel System for Detecting Developmental Neurotoxicity of Chemicals using Zebrafish2012

    • Author(s)
      Nishimura Y
    • Organizer
      2012 ICCA-LRI and UK HPA Workshop Technologies to Inform Chemical Safety Sciences
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュを用いた新しい発達神経毒性評価システム

    • Author(s)
      西村有平、島田康人、田中利男
    • Organizer
      日本先天異常学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ゼフラフィッシュを用いた網膜毒性評価

    • Author(s)
      西村有平
    • Organizer
      比較眼科学会基礎部会
    • Place of Presentation
      住友化学
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 三重大学大学院医学系研究科薬理ゲノミクス

    • URL

      http://pgx.medic.mie-u.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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