Identification of the repair enzymes for oxidatively damaged bases-Analysis of the mechanism for protection of ionizing radiation and reactive oxygen species
Project/Area Number |
24510071
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 酸化的損傷塩基 / DNA修復 / 活性酸素 / 電離放射線 / 突然変異 / 線虫 / 酸化ストレス / 放射線 / 塩基損傷 / 酸化的塩基損傷 / 塩基除去修復 / 酸化ストレス防御 / OXR1 / Exo-3 / NudX / Nudix |
Outline of Final Research Achievements |
Reactive oxygen species (ROS) are generated continually in living cells during normal cellular metabolism and also generated by exogenous sources such as ionizing radiation and various chemical oxidants. ROS are highly reactive and damage DNA, causing strand breaks and many types of damaged bases. If such damages are not eliminated or repaired, they lead to cellular dysfunction, cell death, mutations, cancer and aging. Cells protect themselves from ROS by preventing oxidative cellular damage, through repair of oxidative damages. In this study, we identified several DNA repair enzymes from C. elegans, and clarified their involvement in aging, embryo development and body growth. We also analysed the role of DNA repair enzymes against biological consequences of ionising radiation.
|
Report
(5 results)
Research Products
(101 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells2012
Author(s)
Hosoki, A., S. Yonekura, Q-L. Zhao, Z-L. Wei, I. Takasaki, Y. Tabuchi, L-L. Wang, S. Hasuike, T. Nomura, A. Tachibana, K. Hashiguchi, S. Yonei, T. Kondo and Q-M. Zhang-Akiyama
-
Journal Title
Journal of Radiation Research
Volume: 53
Issue: 1
Pages: 58-71
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 天然生薬複合剤KPGの抗酸化能力の多面的解析2015
Author(s)
加藤誠嗣, 吉川幸宏, 松井亜子, 小川幸大, 松本謙一郎, 中西郁夫, 加藤悠一, 田中雅, 秋山(張)秋梅
Organizer
第15回AOB研究会「抗酸化物質の役割:AOBの力と未来への展望」
Place of Presentation
スイスホテル南海大阪
Year and Date
2015-07-03
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-