Can radiation increase the risk of cardiovascular diseases? Evaluation by animal model studies.
| Project/Area Number |
24510080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHISHI Waka 放射線影響研究所, 臨床研究部(広島), 部長 (20393423)
NIWA Yasuharu 放射線影響研究所, 分子生物科学部, 副主任研究員 (40284286)
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| Co-Investigator(Renkei-kenkyūsha) |
NABIKA Tohru 島根大学, 医学部・病態病理学, 教授 (50180534)
INABA Toshiya 広島大学, 原爆放射線医科学研究所・がん分子病態研究分野, 教授 (60281292)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 循環器疾患 / 動物実験 / 放射線影響 / リスク推定 / 作用機序 |
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| Outline of Final Research Achievements |
Data from epidemiological studies for the atomic-bomb survivors indicate that risk for circulatory diseases (CDs) were associated with radiation exposure. In this study, we intend to assess the relationship between CDs and radiation exposure by animal model studies and to obtain information about biological mechanisms.
In the studies using stroke prone spontaneous hypertensive rat (SHRSP), the life span of irradiated rats was significantly shorter than unirradiated rats, and the damage, such as cerebral hemorrhage, in irradiated rats was more advanced than that observed in the organs of unirradiated rats. On the other hand, in the studies using spontaneous hypertensive rat (SHR), the systolic blood pressure level of irradiated rats increased with increasing of dose. Moreover, the amount of various blood biomarkers increased/decreased according to the radiation doses. The results revealed that our studies can play important roles to hypothesize on the mechanisms.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] A report from the 2013 International Workshop: Radiation and Cardiovascular Disease, Hiroshima, Japan2013
Author(s)
Takahashi I, Ohishi W, Mettler FA Jr, Ozasa K, Jacob P, Ban N, Lipshultz SE, Stewart FA, Nabika T, Niwa Y, Takahashi N, Akahoshi M, Kodama K and Shore R
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Journal Title
J Radiol Prot
Volume: 33(4)
Issue: 4
Pages: 869-880
DOI
Related Report
Peer Reviewed
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[Presentation] Study of radiation related circulatory diseases using animal models, Part II: Evaluating feasibility of spontaneous hypertensive rat (SHR) as an animal model2014
Author(s)
Y. Niwa, H. Murakami, W. Ohishi, M. Misumi, Y. Kusunoki, A. Nagamachi, T. Inaba, S. Tanaka, I. Braga-Tanaka, N. Takahashi
Organizer
The Sixth International MELODI Workshop
Place of Presentation
バルセロナ、スペイン
Year and Date
2014-10-07 – 2014-10-09
Related Report
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[Presentation] Study of radiation related circulatory diseases using animal models, Part II: Evaluating feasibility of spontaneous hypertensive rat (SHR) as an animal model2014
Author(s)
N. Takahashi, H. Murakami, W. Ohishi, M. Misumi, Y. Kusunoki, A. Nagamachi, T. Inaba, Y. Oghiso, S. Tanaka, I. Braga-Tanaka , Y. Niwa
Organizer
60th Annual Meeting of the Radiation Research Society
Place of Presentation
ラスベガス、米国
Year and Date
2014-09-21 – 2014-09-24
Related Report
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