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Comparative toxicology of triazine herbicides focusing on delayed metamorphosis and malformations during the postembryonic development of anurans

Research Project

Project/Area Number 24510088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKyoto Prefectural Institute of Public Health and Environment

Principal Investigator

SAKA Masahiro  京都府保健環境研究所, 水質課, 主任研究員 (80419192)

Co-Investigator(Renkei-kenkyūsha) TADA Noriko  京都府保健環境研究所, 水質課, 主任研究員 (70419191)
Research Collaborator KAMATA Yoichi  岩手大学, 農学部, 教授 (20152837)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカエル / 後期発生 / トリアジン / 除草剤 / 成長阻害 / 発生遅延 / 奇形 / 甲状腺 / カエル変態試験 / ネッタイツメガエル / 催奇形性 / 成長遅延
Outline of Final Research Achievements

Triazines have been commonly used as herbicides on a global scale. Although toxic effects of triazines have been intensively studied, chronic toxicity of triazines on amphibians is still controversial. We revealed non-lethal toxic effects of seven triazine herbicides on the anuran postembryonic development by conducting long-term exposure tests using premetamorphic tadpoles of Western clawed frogs. Our morphometric results consistently indicated that the triazines acted as a chemical stressor inhibiting tadpole growth and/or development in a thyroid-inactive mode. In addition, it was demonstrated that the triazines had teratogenicity to induce axial malformations in developing tadpoles.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 2 results) Remarks (4 results)

  • [Journal Article] Application of an amphibian (Silurana tropicalis) metamorphosis assay to the testing of the chronic toxicity of three rice paddy herbicides: Simetryn, mefenacet, and thiobencarb2013

    • Author(s)
      Masahiro Saka, Noriko Tada, and Yoichi Kamata
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 92 Pages: 135-143

    • DOI

      10.1016/j.ecoenv.2013.03.023

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Examination of an amphibian metamorphosis assay under an individual-separated exposure system using Silurana tropicalis tadpoles2012

    • Author(s)
      Masahiro Saka, Noriko Tada, and Yoichi Kamata
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 86 Pages: 86-92

    • DOI

      10.1016/j.ecoenv.2012.08.034

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] クロロトリアジン系除草剤によるカエル後期発生への毒性影響について2014

    • Author(s)
      坂 雅宏、多田 哲子、鎌田 洋一
    • Organizer
      日本爬虫両棲類学会 第53回大会
    • Place of Presentation
      神戸市(神戸山手大学)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chronic toxicity of triazine herbicides on the postembryonic development of Xenopus (Silurana) tropicalis2014

    • Author(s)
      Masahiro Saka, Noriko Tada, Yoichi Kamata
    • Organizer
      The 8th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology
    • Place of Presentation
      岡崎市(岡崎国立共同研究機構 基礎生物学研究所)
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Chronic toxicity of triazine herbicides on the postembryonic development of Xenopus (Silurana) tropicalis2014

    • Author(s)
      Masahiro Saka, Noriko Tada, Yoichi Kamata
    • Organizer
      Society of Environmental Toxicology and Chemistry, Asia/Pacific Meeting
    • Place of Presentation
      Adelaide Convention Centre (Australia)
    • Year and Date
      2014-09-15 – 2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロロトリアジン系除草剤によるカエル後期発生への毒性影響について2014

    • Author(s)
      坂 雅宏、多田 哲子、鎌田 洋一
    • Organizer
      第20回日本環境毒性学会研究発表会
    • Place of Presentation
      富山県(富山国際会議場)
    • Year and Date
      2014-09-10 – 2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 両生類の環境毒性学2014

    • Author(s)
      坂 雅宏
    • Organizer
      (独)農業環境技術研究所生物多様性研究領域セミナー
    • Place of Presentation
      つくば市(農業環境技術研究所)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] メチルチオトリアジン系除草剤によるカエル後期発生への毒性影響について2013

    • Author(s)
      坂 雅宏、多田 哲子、鎌田 洋一
    • Organizer
      第19回日本環境毒性学会研究発表会
    • Place of Presentation
      東京都(東洋大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] メチルチオトリアジン系除草剤によるカエル後期発生への毒性影響について2013

    • Author(s)
      坂 雅宏、多田 哲子、鎌田 洋一
    • Organizer
      日本爬虫両棲類学会第52回大会
    • Place of Presentation
      札幌市(東海大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] Chronic toxicity tests of three rice paddy herbicides on Silurana tropicalis tadpoles using a modified amphibian metamorphosis assay2012

    • Author(s)
      Masahiro Saka, Noriko Tada, and Yoichi Kamata
    • Organizer
      Society of Environmental Toxicology and Chemistry Asia Pacific Meeting
    • Place of Presentation
      熊本市
    • Related Report
      2012 Research-status Report
  • [Remarks] 京都府保健環境研究所事業概要(平成26年度)

    • URL

      http://www.pref.kyoto.jp/hokanken/documents/jigyougaiyou_h26.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都府保健環境研究所年報第59号

    • URL

      http://www.pref.kyoto.jp/hokanken/documents/nenpou59-99.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都府保健環境研究所事業概要(平成25年度)

    • URL

      http://www.pref.kyoto.jp/hokanken/documents/jigyougaiyou_h25.pdf

    • Related Report
      2013 Research-status Report
  • [Remarks] 京都府保健環境研究所事業概要(平成24年度)

    • URL

      http://www.pref.kyoto.jp/hokanken/documents/jigyougaiyou_h24.pdf

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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