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Search for sequence-dependent allele-specific hydroxymethylation

Research Project

Project/Area Number 24510266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Genome biology
Research InstitutionKanazawa University

Principal Investigator

YAMADA yoichi  金沢大学, 電子情報学系, 准教授 (30377402)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsヒドロキシメチル化
Outline of Final Research Achievements

The research representative previously reported a sequence-dependent allele-specific methylation. This enabled us to interpret the mechanism of various disease susceptibility caused by sequence polymorphisms through gene expression differences caused by the presence or absence of genomic methylation at a polymorphic site. On the other hand, genomic hydroxymethylation plays an important role in the demethylation process. Furthermore, it is suggested that genomic hydroxymethylation is also involved in gene expression regulation. In this study, we examined whether the six known sequence-dependent allele-specific methylation regions in mouse are subject to a sequence-dependent allele-specific hydroxymethylation. As a result, it was shown that one of the six was subject to a sequence-dependent allele-specific hydroxymethylation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Factors to preserve CpG-rich sequences in methylated CpG islands2015

    • Author(s)
      Hiroki Miyahara, Osamu Hirose, Kenji Satou, Yoichi Yamada
    • Journal Title

      BMC Genomics

      Volume: Vol.16 Issue: 1 Pages: 144-144

    • DOI

      10.1186/s12864-015-1286-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regional DNA Methylation Differences between Humans and Chirnpanzees Are Associated with Genetic Changes, Transeriptional Divergence and Disease Genes2013

    • Author(s)
      福田 渓
    • Journal Title

      J. Hum, Genet

      Volume: 58 Issue: 7 Pages: 446-54

    • DOI

      10.1038/jhg.2013.55

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of MIMGO: a method to identify differentially expressed GO terms in a microarray dataset2012

    • Author(s)
      Yoichi Yamada, Hiroki Sawada, Ken-ichi Hirotani, Masanobu Oshima, Kenji Satou
    • Journal Title

      BMC Research Notes

      Volume: Vol.5:680 Issue: 1

    • DOI

      10.1186/1756-0500-5-680

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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