| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
We investigated whether exposure to nicotine during adolescence in mice affects their cognitive abilities at adulthood. Mice were tested for place learning task and simple reaction time task. Nicotine-treated mice acquired place learning task as well as control mice did. However, they showed a deficit in reversal learning. In a simple reaction time task, nicotine-treated mice revealed diminished performance of attention, without impulsive action. We also found decreases of the dendrite length and the dendrite complexity in the medial prefrontal cortex and of nicotine-treated mice during adolescence. Our results suggest that adolescent nicotine exposure can induce long-lasting morphological changes in the brain and persistent cognitive deficits in mice.
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