The effects of blood pressure changes on cognitive function in rats
Project/Area Number |
24530917
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental psychology
|
Research Institution | Tohoku Bunka Gakuen University |
Principal Investigator |
SATO Toshihiko 東北文化学園大学, 健康社会システム研究科, 准教授 (20322612)
|
Project Period (FY) |
2012-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | SHR / WKY / ラット / 遅延照合課題 / オペラント条件づけ / 記憶 / 血圧 / 血管拡張薬 / 選択反応時間課題 / 注意 / 遅延場所照合課題 / 5選択反応時間課題 |
Outline of Final Research Achievements |
This study aimed to study the effect of blood pressure reduction on cognitive function in rats. In this research, we used spontaneously hypertensive rats (SHR) with higher blood pressure levels based on their genetic background. We compared these animals to normal controls of the Wistar-Kyoto strain (WKY). A retention gradient between 0 and 20 seconds was determined on the basis of the number of correct responses in a working memory task (a delayed-matching-to-place task, DMTP). Their performance was compared. The number of correct responses decreased after injection of the vasodilator hydralazine (0.3 and 0.6 mg/kg) compared to the injection of a vehicle, saline. The difference between these dosages was relatively small and difference in performance in this DMTP task was not evident between SHR and WKY rats. There were some strain differences in the response latency, as an index of response speed, in some simpler learning task (e.g., autoshaping).
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Report
(6 results)
Research Products
(30 results)