Deeping of molecular-level understanding of biological damage mechanisms by low-energy electrons
| Project/Area Number |
24550008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線損傷 / 電子衝突 / 解離性電子付着 / 分子アニオン / 水和電子 / 反応動力学 / 量子化学計算 / ポテンシャルエネルギー曲面 / 量子動力学 / 電子状態理論 / 共鳴アニオン / 溶媒和電子 |
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| Outline of Final Research Achievements |
Although it has been pointed out that secondary electrons with low energy, that are produced from high-energy radiation, can cause significant biological damage, its dynamical mechanisms have not yet been fully understood. We have performed systematic theoretical research on dynamics of radiation damage of biomolecules by low-energy electrons from a theoretical viewpoint. We have explored the binding mechanism of excess electrons in various biological systems including base pair using quantum chemical calculations. In addition, we carried out quantum dynamics simulations that can describe all atomic motions quantum mechanically. The results provide real-time understanding of radiation damage mechanisms by low-energy electrons.
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Report
(4 results)
Research Products
(33 results)
