| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
A chromatographic method based on the moment theory was developed for analyzing not only the equilibrium but also the reaction kinetics of intermolecular interaction. New moment equations were also developed by assuming that the reaction kinetics between solute molecules and functional ligands could be represented by the Langmuir-type rate equation. They are essential for determining the association and dissociation rate constants from chromatographic elution peak profiles experimentally measured.
As concrete examples, it was tried to determine the association and dissociation rate constants in two different chiral separation systems. Thermodynamic characteristics of the reaction kinetics relating to the intermolecular interaction were also determined by analyzing the temperature dependence of the rate constants. It was demonstrated that chromatography was effective for the kinetic study of intermolecular interaction, although it has widely been used as a separation method.
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