Asymmetric construction of a stereogenic carbon center substituted with aryl groups
Project/Area Number |
24550117
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Synthetic chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
|
Research Collaborator |
EBE Yusuke
NAGAMOTO Midori
TAKECHI Ryosuke
HATANO Miyuki
YAMAUCHI Daisuke
NAGAI Tomotaka
FUJIMOTO Hiroto
NOISHIKI Akira
TAKIGUCHI Yuka
MAEDA Yuko
ASHOURI Akram
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 不斉合成 / 触媒反応 / ロジウム / アリールボロン酸 / イリジウム / 金属触媒 / アリール化 / イミン / アミノ酸 / 不斉付加 / 触媒 / 不斉4置換炭素 / アミン / 付加反応 |
Outline of Final Research Achievements |
We have developed Rh-catalyzed arylation methods by use of arylboron reagents for the synthesis of chiral compounds having a stereogenic carbon center that is substituted with aryl groups. The use of chiral diene ligands base on a tetrafluorobenzobarrelene (tfb) framework was found to be effective in catalyzing the arylation reaction with high enantioselectivity. It was also found that Ir-catalyzed annulation of aromatic imines with 1,3-dienes or alkynes proceeds via C-H bond activation with high stereoselectivity.
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Report
(4 results)
Research Products
(24 results)