Development of a boric acid-capturing molecular device using inositol ring inversion
Project/Area Number |
24550148
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional materials chemistry
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
YUASA Hideya 東京工業大学, 生命理工学研究科, 教授 (90261156)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 環反転 / リポソーム / 蝶番糖 / イノシトール / ホウ酸 / 中性子線治療 / ホウ酸センサー / ホウ酸捕捉樹脂 |
Outline of Final Research Achievements |
Monosaccharides like glucose have a foldable hexagonal structure. They can be exploited as a component of motional molecular devices, if we can control the folding structure by a signal molecule. We synthesized a monosaccharide with two long methylene chains that can change structures from linear to parallel chains by zinc ion. This monosaccharide with zinc ion forms a lipid bilayer structure by aggregation like cell membrane lipids, enabling incorporation of a lipophilic substance. In acidic conditions, this liposome structure is decomposed releasing the inner substances, because the parallel chain is turned back into the linear chain. The stimuli responsive liposome can be a new drug delivery system.
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Report
(4 results)
Research Products
(23 results)