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Development of PLLA Nanofiber Scaffold Doped with BaTiO3 by Electrospinning for Bone/Cartilage Tissue Engineering

Research Project

Project/Area Number 24560114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionDoshisha University

Principal Investigator

MORITA Yusuke  同志社大学, 生命医科学部, 教授 (80368141)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords骨軟骨再生 / スキャホールド / ナノファイバー / チタン酸バリウム粒子 / エレクトロスピニング / 圧電材料
Outline of Final Research Achievements

In this study, PLLA nanofiber scaffold doped with BaTiO3 (BTO) particle was developed to accelerate bone formation. We developed PLLA/BTO nanofiber scaffold with uniformly dispersed BTO nanoparticles at PLLA concentration of 10 w/v% and BTEAC concentration of 3 w/v%. According to TEM observation, BTO nanoparticles were dispersed uniformly in the PLLA/BTO nanofiber, and the density of BTO nanoparticle in the PLLA/BTO nanofiber increased with increasing amount of BTO. The surface potential of PLLA/BTO nanofiber was lower than that of PLLA nanofiber due to BTO nanoparticles. There were no differences in DNA amount among all nanofiber scaffold. ALP activity on PLLA/BTO nanofiber scaffold was higher than that on PLLA nanofiber scaffold. It was suggested that PLLA/BTO nanofiber scaffold enhanced osteogenic differentiation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Presentation (5 results)

  • [Presentation] エレクトロスピニングによる骨再生のためのBaTiO3添加PLLAナノファイバースキャホールドの創製2015

    • Author(s)
      山野彩花,森田有亮,仲町英治
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of PLLA/BTO Nanofiber Sheet for Bone Tissue Engineering2014

    • Author(s)
      Yamano, A., Morita Y. and Nakamachi, E.
    • Organizer
      26th Annual Conference European Society for Biomaterials
    • Place of Presentation
      Liverpool
    • Year and Date
      2014-08-31 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] エレクトロスピニング法による多孔質構造を有する組織再生用PLLA ファイバースキャホールドの開発2014

    • Author(s)
      成定涼介,森田有亮,南元一希,仲町英治
    • Organizer
      日本機械学会 関西学生会平成25年度学生員卒業研究発表講演会
    • Place of Presentation
      大阪府立大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨形成促進のためのBaTiO3粒子添加PLAナノファイバースキャホールドの開発2013

    • Author(s)
      山野 彩花,森田 有亮,垂永 明彦,仲町 英治
    • Organizer
      平成24年度日本機械学会関西学生会学生員卒業研究発表講演会,
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Research-status Report
  • [Presentation] エレクトロスピニング法による階層構造を有する軟骨再生用PLAナノファイバースキャホールドの開発2013

    • Author(s)
      南元一希,森田有亮,垂永明彦,仲町英治
    • Organizer
      平成24年度日本機械学会関西学生会学生員卒業研究発表講演会
    • Place of Presentation
      大阪工業大学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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