Systematic screening of genes interacting with protein phosphatases and analysis of their new mechanism for chromosome function.

Research Project

Project/Area Number	24570195
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Molecular biology
Research Institution	Kyoto University
Principal Investigator	NAKASEKO Yukinobu 京都大学, 生命科学研究科, 准教授 (30231468)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	染色体構築 / 染色体機能 / 染色体分配 / 染色体構築・機能・分配
Outline of Final Research Achievements	Many proteins are known to have various modifications for functional regulation in the cell. Among them, phosphorylation/dephosphorylation is one of the major modifications that regulates activity of protein itself or interactions with other molecules. In this study, multiple genes that functionally interact with the protein phosphatases were identified and analyzed by a comprehensive genetic approach using fission yeast.