| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In animal cells, the contractile ring (CR) is formed beneath the plasma membrane in a foredivision site after nuclear division, and the CR constricts to pinch the cell into two. However, cytokinetic signal has not been uncovered in the closed mitosis organisms including yeasts and protozoa. The fission yeast Schizosaccharomyces pombe is an ideal organism for studying the molecular mechanism of cytokinesis. In this organism, CR is found in a dividing site as well as in animal cells, but its assembly is completed prior to the onset of nuclear division. In this project, we investigated a role of proteins responsible for the cytokinetic signal in S. pombe and its related species. As a result, we found that the major regulatory protein for CR assembly in S. pombe plays only an auxiliary role in the other species. Thus, fission yeasts probably have multiple cytokinetic-signalling systems, and the dependencies on each system may be different between the species.
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