Analysis of the mechanism of fatty acid synthesis regulation by a novel feeding response gene and its application in anti-obesity therapy
| Project/Area Number |
24580175
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
INOUE Jun 東京大学, 農学生命科学研究科, 准教授 (70323962)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 脂肪酸合成 / 脂肪肝 / LXR / ACC / 抗肥満 |
|---|
| Outline of Final Research Achievements |
We demonstrated that MIG12, a novel feeding response gene, stimulates the activity of ACC by accelerating ACC polymer formation. We also showed that leucine zipper domains located at the C-terminal of MIG12 contribute to the regulation of ACC. These results indicate that MIG12 is a novel modulator of lipogenesis.
|
Report
(4 results)
Research Products
(4 results)
