Effect of plant phospholipid on integrity of gastrointestinal mucosa
| Project/Area Number |
24580185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TANAKA Tamotsu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (90258301)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUMURA Akira 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (00035560)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リン脂質 / 植物性食品 / 消化管 / 粘液分泌 / 脂質メディエーター / リゾホスファチジン酸 / ホスファチジン酸 / 胃粘膜 / 表層粘液細胞 / ムチン / アスピリン潰瘍 / 消化管粘膜 / 抗消化性潰瘍 / 植物 / phospholipid / lysophosphatidic acid / phosphatidic acid / anti-ulcer / ceramide-1-phosphate / apoptosis / prostaglandin E2 / cyclooxygenase 2 |
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| Outline of Final Research Achievements |
Effects of plant phospholipids and its digests on epithelial integrity of gastrointestinal (GI) tract were studied. We found that lysophosphatidic acid (LPA) up-regulates mRNA levels of MUC1 and cyclooxygenase 2, and enhances prostaglandin E2 (PGE2) production in human gastric cell line. We also found that LPA induces secretion of vesicles which contain cytosolic mucin. The mucin and PGE2 are known as cytoprotective factors in stomach. The newly identified sphingophospholipid in cabbage, phyto-ceramide-1-phosphate, was found to have secretion enhancing activity in gastric cells. These phospholipids are rare in meets and abundantly contained in Cruciferous vegetables. The beneficial effects of ingestion of Cruciferous vegetables on damaged GI tract may be explained by the action of these plant-derived phospholipids.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] 歯周病におけるリゾホスファチジン酸の役割2014
Author(s)
橋村慧, 松田璃沙, 稲垣裕司, 松井寛和, 横田美帆, 田中保, 木戸淳一, 永田俊彦, 徳村彰
Organizer
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
Place of Presentation
広島国際会議場（広島県広島市）
Year and Date
2014-11-09
Related Report
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[Presentation] 種々のセラミド-1-リン酸の生理活性2014
Author(s)
田畑優美香, 山下量平, 伊賀永里奈, 喜田孝史, 安藤千恵, 徳村彰, 田中保
Organizer
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
Place of Presentation
広島国際会議場（広島県広島市）
Year and Date
2014-11-09
Related Report
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[Presentation] Identification of a sphingolipid-specific phospholipase D activity associated with the generation of phytoceramide-1-phosphate in cabbage leaves
Author(s)
Tamotsu Tanaka, Takashi Kida, Hiroyuki Imai, Jun-ichi Morishige, Ryouhei Yamashita, Hisatsugu Matsuoka, Sachika Uozumi, Kiyoshi Satouchi, Minoru Nagano, and Akira Tokumura
Organizer
2013 FASEB Summer Research Conference, Lysophospholipid and other related mediators –From Bench to Clinic-
Place of Presentation
ヒルトンニセコビレッジ（北海道）
Related Report
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