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Ameriolation of adipocyte function by targeting hypoxic stress

Research Project

Project/Area Number 24580193
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionUniversity of Miyazaki

Principal Investigator

YAMASAKI Masao  宮崎大学, 農学部, 准教授 (80381060)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords低酸素ストレス / 脂肪細胞 / 低酸素 / 線維化 / 糖尿病
Outline of Final Research Achievements

We evaluated the effect of hypoxia on the function of adipocytes and the ameliorative effect of food components on the hypoxic stress.
Hypoxic stress elicited the disruption of homeostasis of adipokine production such as reduction of adiponectin production and its oligomerization. On the other hand, some food components were capable of ameliorating this hypoxic stress. Taken together, our results provide a novel target of life style diseases that can be a useful for the development of functional food.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (23 results) (of which Invited: 3 results) Remarks (2 results)

  • [Journal Article] Suppressing effect of cordycepin on the lipopolysaccharide- induced nitric oxide production in RAW 264.7 cells.2015

    • Author(s)
      K. Imamura, M. Asai, T. Matsumoto, Y.Yamasaki, I. Kamei, T. Hattori, M. Kishimoto, S. Niisaka, M. Kubo, K. Nishiyama, M. Yamasaki
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: in press Issue: 6 Pages: 1021-1025

    • DOI

      10.1080/09168451.2015.1008977

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion; proteomic approach using fluorescent two-dimensional differential gel electrophoresis2014

    • Author(s)
      Yo-ichi Ishida, Masao Yamasaki, Chizuko Yukizaki, Kazuo Nishiyama, Hirohito Tsubouchi, Akihiko Okayama, Hiroaki Kataoka
    • Journal Title

      Human Cell

      Volume: 27(2) Issue: 2 Pages: 68-77

    • DOI

      10.1007/s13577-013-0083-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells.2014

    • Author(s)
      M. Yamasaki, S. Soda, Sakakibara, M. Suiko, and K. Nishiyama.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 78 Issue: 11 Pages: 1939-1942

    • DOI

      10.1080/09168451.2014.943647

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delta-tocotrienol induces apoptotic cell death via depletion of intracellular squalene in ED40515 cells.2014

    • Author(s)
      M. Yamasaki, M. Nishinura, Y. Sakakibara, M. Suiko, K. Morishita, K. Nishiyama.
    • Journal Title

      Food Funct

      Volume: 5 Issue: 11 Pages: 2842-2849

    • DOI

      10.1039/c4fo00635f

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells2014

    • Author(s)
      Masao Yamasaki, Masahiro Iwase, Kazuo Kawano, Yoichi Sakakibara, Masahito Suiko, Masahiro Ikeda, Kazuo Nishiyama
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 1 Pages: 18-25

    • DOI

      10.3164/jcbn.13-57

    • NAID

      130004466739

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipocyte response to conjugated linoleic acid.2014

    • Author(s)
      Yamasaki M, Yanagita T.
    • Journal Title

      Obes Res Clin Pract

      Volume: 7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptotic cell death in HL-60 cells by jacaranda seed oil derived fatty acids.2014

    • Author(s)
      Yamasaki M, Motonaga C, Yokoyama M, Ikezaki A, Kakihara T, Hayasegawa R, Yamasaki K, Sakono M, Sakakibara Y, Suiko M, Nishiyama K.
    • Journal Title

      J Oleo Sci

      Volume: 62 Pages: 925-32

    • NAID

      40019836642

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 共役脂肪酸の機能性食品成分への応用に関する研究2013

    • Author(s)
      山崎正夫
    • Journal Title

      日本栄養・食糧学会誌

      Volume: 66 Pages: 241-248

    • NAID

      10031201223

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genistein induces apoptotic cell death associated with inhibition of the NF-B pathway in adult T-cell leukemia cells2013

    • Author(s)
      Masao Yamasaki, Yoshihiro Mine, Misato Nishimura, Satoshi Fujita, Yoichi Sakakibara, Masahito Suiko, Kazuhiro Morishita and Kazuo Nishiyama
    • Journal Title

      Cell Biology International

      Volume: 37 Issue: 7 Pages: 742-747

    • DOI

      10.1002/cbin.10101

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-<i>ras</i>-transformed 3Y1 cells2012

    • Author(s)
      M. Yamasaki, M. Iwase, K. Kawano, Sakakibara, M. Suiko, and K. Nishiyama.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 50 Issue: 3 Pages: 234-240

    • DOI

      10.3164/jcbn.11-67

    • NAID

      130004879270

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Highly Lipolyzed Goat Cheese on HL-60 Human Leukemia Cells:Antiproliferative Activity and Induction of Apoptotic DNA Damage.2012

    • Author(s)
      Tachibana, H. et al.
    • Journal Title

      J. Dairy Sci.

      Volume: 95 Issue: 5 Pages: 2248-2260

    • DOI

      10.3168/jds.2011-4153

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Apocynin Selectively Inhibits Proliferation, Adhesion to Fibronectin of v-H-ras-transformed 3Y1 Cells2012

    • Author(s)
      M. Yamasaki, M. Iwase, K. Kawano, Sakakibara, M. Suiko, and K. Nishiyama.
    • Journal Title

      Bioscience Biotechnology Biochemistry

      Volume: 76 Pages: 1177-1181

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conjugated linoleic acids inhibit hypoxia inducible factor-1alpha stabilization under hypoxic condition in human hepatocellular carcinoma cells2012

    • Author(s)
      M Yamasaki, T Nagatomo, T Matsuyama, Y Ikeho, E Kato, K Nishiyama, Y. Sakakibara, M Suiko, K Nishiyama
    • Journal Title

      Journal of Oleo Science

      Volume: 61 Pages: 491-496

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo2012

    • Author(s)
      Shinohara, N., Tsuduki T., Ito, J., Honma, T., Kijima, R., Sugawara, S., Arai, T., Yamasaki, M., Ikezaki, A., Yokoyama, M., Nishiyama, K., Nakagawa, K., Miyazawa, T., Ikeda, I.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1821 Issue: 7 Pages: 980

    • DOI

      10.1016/j.bbalip.2012.04.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] β1-Integrin plays an important role in fucoidan-induced apoptosis via caspase-8 activation.2012

    • Author(s)
      Y. Yamasaki, M. Yamasaki, H. Tachibana, K. Yamada
    • Journal Title

      Bioscience Biotechnology Biochemistry

      Volume: 76 Pages: 980-988

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, inhibits stearoyl-CoA desaturase activity in mice2012

    • Author(s)
      N Shinohara, T Tsuduki, J Ito, T Honma, R Kijima, S Sugawara, T Arai, M Yamasaki, A Ikezaki, M Yokoyama, K Nishiyama, K Nakagawa, T Miyazawa, I Ikeda.
    • Journal Title

      Journal of Oleo Science

      Volume: 61 Pages: 433-441

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ブルーベリー葉抽出物によるインスリン抵抗性改善作用2015

    • Author(s)
      松山勇介、早瀬川倫太郎、濱田健作、甲斐孝憲、亀長浩蔵、松浦靖、柚木崎千鶴子、西山和夫、山崎正夫
    • Organizer
      日本農芸化学会2015年度(平成27年度)大会
    • Place of Presentation
      岡山大学:岡山
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブルーベリー葉抽出物(BLEx)のアルコール代謝亢進作用およびアルコール性肝障害抑制作用2015

    • Author(s)
      山崎楓、河村由樹、長友宏賢、菅本和寛、甲斐孝憲、亀長浩蔵、竹下正彦、菊地幸治、松浦靖、柚木崎千鶴子、江藤敏治、西山和夫、山崎正夫
    • Organizer
      日本農芸化学会2015年度(平成27年度)大会
    • Place of Presentation
      岡山大学:岡山
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 共役リノール酸ナノエマルションによる炎症性腸疾患の病態改善作用2015

    • Author(s)
      金崎寿敏、木下和昭、山本建次、濱山真吾、清水正高、西山和夫、山崎正夫
    • Organizer
      日本農芸化学会2015年度(平成27年度)大会
    • Place of Presentation
      岡山大学:岡山
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブルーベリー葉抽出物によるアディポネクチン産生調節機構2014

    • Author(s)
      松山勇介、甲斐孝憲、亀長浩蔵、松浦靖、柚木崎千鶴子、奥澤亜美、坂下真実、森田直樹、西山和夫、山崎正夫
    • Organizer
      日本食品科学工学会西日本支部大会
    • Place of Presentation
      九州大学:福岡
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 炎症性腸疾患の病態改善を目標とした共役リノール酸ナノエマルションの応用2014

    • Author(s)
      金崎寿敏、木下和昭、山本建次、濱山真吾、清水正高、西山和夫
    • Organizer
      日本食品科学工学会西日本支部大会
    • Place of Presentation
      九州大学:福岡
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] δ-トコトリエノールによる成人T細胞性白血病致死効果2014

    • Author(s)
      山崎正夫、西村海里、榊原陽一、水光正仁、森下和広、西山和夫
    • Organizer
      19th JSoFF
    • Place of Presentation
      鹿児島大学:鹿児島
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cordycepinによる抗炎症作用のメカニズム解明2014

    • Author(s)
      今村健太、浅井桃子、菅本和寛、松本朋子、山崎有美、亀井一郎、服部貴博、岸本正興、新坂誠司、西山和夫、山崎正夫
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイア:宮崎
    • Year and Date
      2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂質ナノエマルションの抗がん作用に関する研究2014

    • Author(s)
      木下和昭、山本建次、濱山真吾、清水正高、西山和夫、山崎正夫
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイア:宮崎
    • Year and Date
      2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪細胞の低酸素ストレスを標的とした機能性食品成分探索2014

    • Author(s)
      柿原知加、古賀絢子、西山和夫、山崎正夫
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイア:宮崎
    • Year and Date
      2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ブルーベリー葉抽出物(BLEx)のアルコール性肝障害抑制作用2014

    • Author(s)
      山崎楓、河村由樹、西山和夫、甲斐孝憲、亀長浩蔵、竹下正彦、菊地幸治、松浦靖、柚木崎千鶴子、山崎正夫
    • Organizer
      2014年度生物機能研究会
    • Place of Presentation
      九州地区国立大学九重共同研修所:大分
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪組織の線維化抑制を標的とした肥満関連疾患予防2014

    • Author(s)
      早瀬川倫太郎、西山和夫、山崎正夫
    • Organizer
      2014年度生物機能研究会
    • Place of Presentation
      九州地区国立大学九重共同研修所:大分
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂質ナノエマルションの抗がん作用に関する研究2014

    • Author(s)
      木下和昭、金崎寿敏、茨木佳代、板倉祥子、山本建次、清水正高、窄野昌信、山崎正夫、西山和夫
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学:北海道
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪酸による一酸化窒素及びMCP-1産生抑制作用2012

    • Author(s)
      中村崇弘、山崎正夫、西山和夫
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 植物由来共役トリエン型脂肪酸の癌増殖抑制効果2012

    • Author(s)
      都築 毅、篠原菜穂子、山崎正夫、池崎 綾、横山真梨乃、西山和夫、池田郁男
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] トコトリエノールによるATL細胞の増殖抑制効果2012

    • Author(s)
      西村海里、峰善広、森下和広、榊原陽一、水光正仁、山崎正夫、西山和夫
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] α-リポ酸のβ1-integrinを標的とした膀胱ガン細胞の浸潤、転移抑制作用2012

    • Author(s)
      岩瀬将弘、河野和生、山崎正夫、西山和夫
    • Organizer
      第7回αリポ酸研究会
    • Place of Presentation
      京都府立大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 冬虫夏草(Cordyceps militaris)の抗炎症作用2012

    • Author(s)
      今村健太、浅井桃子、菅本和寛、松本朋子、山崎有美、亀井一郎、服部貴博、岸本正興、新坂誠司、西山和夫、山崎正夫
    • Organizer
      日本農芸化学会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2012 Research-status Report
  • [Presentation] γ-リノレン酸による脂肪細胞とマクロファージにおける抗炎症作用2012

    • Author(s)
      中村崇弘、山崎正夫、西山和夫
    • Organizer
      第3回機能油脂懇話会
    • Place of Presentation
      マホロバマインズ三浦
    • Related Report
      2012 Research-status Report
  • [Presentation] γ-トコトリエノールによるATL細胞の増殖抑制効果2012

    • Author(s)
      西村海里、山崎正夫、森下和広、榊原陽一、水光正仁、西山和夫
    • Organizer
      第9回日本トコトリエノール研究会
    • Place of Presentation
      産業技術総合研究所
    • Related Report
      2012 Research-status Report
  • [Presentation] γ-トコトリエノールによるATL細胞の増殖抑制効果2012

    • Author(s)
      西村海里、山崎正夫、森下和広、榊原陽一、水光正仁、西山和夫
    • Organizer
      フレッシュマンサミットOSAKA 2012
    • Place of Presentation
      近畿大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 共役脂肪酸の機能性食品成分の応用に関する研究

    • Author(s)
      山崎正夫
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 共役脂肪酸の免疫調節作用

    • Author(s)
      山崎正夫
    • Organizer
      九州・沖縄支部および日本食品科学工学会西日本支部合同大会 公開市民フォーラム九州・沖縄支部および日本食品科学工学会西日本支部合同大会 公開市民フォーラム
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Anti-cancerous effect of conjugated fatty acids

    • Author(s)
      Yamasaki, M
    • Organizer
      13 mo Convegno Italo-Giapponese sulla Scienza e Tecnologia Di Miyazaki
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] www.agr.miyazaki-u.ac.jp/~abs/nishiyama_yamasaki

    • Related Report
      2014 Annual Research Report
  • [Remarks] 宮崎大学農学部応用生物科学科食品機能化学講座

    • URL

      http://www.agr.miyazaki-u.ac.jp/~abs/nishiyama_yamasaki/

    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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