Ameriolation of adipocyte function by targeting hypoxic stress
| Project/Area Number |
24580193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 低酸素ストレス / 脂肪細胞 / 低酸素 / 線維化 / 糖尿病 |
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| Outline of Final Research Achievements |
We evaluated the effect of hypoxia on the function of adipocytes and the ameliorative effect of food components on the hypoxic stress.
Hypoxic stress elicited the disruption of homeostasis of adipokine production such as reduction of adiponectin production and its oligomerization. On the other hand, some food components were capable of ameliorating this hypoxic stress. Taken together, our results provide a novel target of life style diseases that can be a useful for the development of functional food.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.2015
Author(s)
K. Imamura, M. Asai, T. Matsumoto, Y.Yamasaki, I. Kamei, T. Hattori, M. Kishimoto, S. Niisaka, M. Kubo, K. Nishiyama, M. Yamasaki
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Journal Title
Biosci Biotechnol Biochem.
Volume: in press
Pages: 1021-1025
DOI
Related Report
Peer Reviewed
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[Journal Article] Induction of apoptotic cell death in HL-60 cells by jacaranda seed oil derived fatty acids.2014
Author(s)
Yamasaki M, Motonaga C, Yokoyama M, Ikezaki A, Kakihara T, Hayasegawa R, Yamasaki K, Sakono M, Sakakibara Y, Suiko M, Nishiyama K.
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Journal Title
J Oleo Sci
Volume: 62
Pages: 925-32
NAID
Related Report
Peer Reviewed
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[Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo.2012
Author(s)
Shinohara, N., Tsuduki T., Ito, J., Honma, T., Kijima, R., Sugawara, S., Arai, T., Yamasaki, M., Ikezaki, A., Yokoyama, M., Nishiyama, K., Nakagawa, K., Miyazawa, T., Ikeda, I.
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Journal Title
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume: 1821
Pages: 980-988
DOI
Related Report
Peer Reviewed
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[Journal Article] Jacaric acid, a linolenic acid isomer with a conjugated triene system, inhibits stearoyl-CoA desaturase activity in mice2012
Author(s)
N Shinohara, T Tsuduki, J Ito, T Honma, R Kijima, S Sugawara, T Arai, M Yamasaki, A Ikezaki, M Yokoyama, K Nishiyama, K Nakagawa, T Miyazawa, I Ikeda.
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Journal Title
Journal of Oleo Science
Volume: 61
Pages: 433-441
Related Report
Peer Reviewed
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