Novel molecular mechanism of oxidative stress-induced anxiety.
| Project/Area Number |
24580202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | vitamin E / tocopherol / anxiety / HPA axis / glucocorticoid / ビタミンE欠乏 / 不安行動 / HPA軸 |
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| Outline of Final Research Achievements |
We have demonstrated that vitamin E deficiency increased anxiety-like behavior in rats. As this anxiogenic effect was not observed in adrenaletomized rats, corticosterone secretion from the adrenal glands may play an important role. Since corticosterone secretion is regulated by the hypothalamic-pituitary-adrenal (HPA) axis, effect of vitamin E deficiency on HPA regulation was investigated in this study. Vitamin E deficiency enhanced corticosterone secretion in response to acute and chronic stress. Administration of ACTH and CRF increased plasma corticosterone while dexamethasone, a synthetic glucocorticoid, decreased corticosterone through negative feedback regulation; vitamin E deficiency did not affect these regulations. Exogenous corticosterone increased anxiety of adrenaletomized rats; this was not affected by vitamin E deficiency. In conclusion, the response of hypothalamus to stress and/or feedback regulation of corticosterone, is possibly altered by vitamin E deficiency.
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Report
(4 results)
Research Products
(54 results)
