| Project/Area Number |
24580204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DOHMAE Sumiko 名古屋市立大学, 医学研究科, 准教授 (70227700)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 行動解析 / apo Eノックアウトマウス / ABCA1 ノックアウトマウス / カベオリン / コレステロール / apo E ノックアウトマウス / ABC A1 トランスポーターノックアウトマウス / IGF / IGF結合タンパク質 / 体温 / apoE ノックアウトマウス / ABC A1ノックアウトマウス / ABC A７ノックアウトマウス / apoE欠損マウス / アディポカイン / 視床下部 / 脂質異常症 / 細胞膜 / カベオラ / 行動 |
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| Outline of Final Research Achievements |
We investigated functions of the central nervous system (CNS) and caveolin distribution/expression using rats fed high-fat diet, apoE knockout (KO) mice and ABC A1 KO mice showing high and low concentration of cholesterol in the plasma, respectively. The high-soybean oil intake induced abnormal regulation of body temperature in the CNS, increase in n-6/n-3 ratio of fatty acid composition of the hypothalamus, decrease in caveolin mRNA expression. On the other hand, apoE KO mice showed spatial cognitive dysfunction and hypoalgesia, and in ABCA1 KO mice, the opposite behavior was observed. Caveolin mRNA expression in the hypothalamus of ABC A1 KO mice was increased, however, the protein did not increase. ABCA7 KO mice did not change expression of caveolin protein.
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