Chemoprevention of microcystin poisoning using fisheries waste
| Project/Area Number |
24580304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | マイクロシスチン / セラミド誘導体 / アメリカオオアカイカ / ナリンジン / フラボノイド / アノイキス抵抗性 / OATP / 健康食品 / 生薬 / 国際情報交換 / 予防医学 |
|---|
| Outline of Final Research Achievements |
The chemical compounds were screened capable of suppressing the cytotoxicity of liver-selective toxin microcystin-LR derived from blue-green algae. This screening was aimed to be the foundation for the establishment of chemical prevention or remedy of liver cancer and liver dysfunction. Ceramide aminoethylphosphonate isolate from skin of the Jumbo flying squid waste potently attenuated the cytotoxicity of microcystin-LR. Furthermore, naringin which is a kind of flavonoid isolated from citrus was also attenuated the cytotoxicity.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Naringin attenuates the cytotoxicty of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells.2015
Author(s)
Takumi, S., Ikema, S., Hanyu, T., Shima, Y., Kurimoto, T., Shiozaki, K., Sugiyama, Y., Park, H., Ando, S., Furukawa, T., Komatsu, M.
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Journal Title
Environ Toxicol Pharmacol
Volume: 39
Issue: 2
Pages: 974-981
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Evaluation and identification of potent angiotensin-I converting enzyme inhibitory peptide derived from dwarf gulper shark (Centrophorus atromarginatus).2015
Author(s)
Ikeda, A., Ichino, H., Kiguchiya, S., Chigwechokha, P., Komatsu, M., Shiozaki, K.
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Journal Title
J. Food Process Pres.
Volume: 39
Issue: 2
Pages: 107-115
DOI
Related Report
Peer Reviewed
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[Journal Article] Microcystin-LR Induces Anoikis Resistance to the Hepatocyte Uptake Transporter OATP1B3-expressing Cell Lines.2014
Author(s)
Takano, H., Takumi, S., Ikema, S., Mizoue, N., Hotta, Y., Shiozaki, K., Sugiyama, Y., Furukawa, T., Komatsu, M.
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Journal Title
Toxicology
Volume: 326
Pages: 53-61
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase.2014
Author(s)
Shiozaki, K., Ryuzono, S., Matushita, N., Ikeda, A., Takeshita, K., Chigwechokha, P., Komatsu, M., Miyagi, T.
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Journal Title
J. Fish Physiol Biochem.
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes)2013
Author(s)
Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T
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Journal Title
Biochimie
Volume: 95
Issue: 2
Pages: 280-289
DOI
Related Report
Peer Reviewed
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